No, because I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology. And we felt, no matter, anything we do to chip away at the problem would be useful. So it was more that that attracted me. And I think the fact that it was large and kind of difficult to come to grips with, yes, it was attractive. Really what was attractive was that it was a fundamental problem.

When I started getting my first fan letters, I made a point to try to respond to every single one. The wins always felt that much more special because I knew I was making so many people happy. And losses hurt that much worse because I truly was invested in not wanting to disappoint those who supported my side. But more than anything, I always appreciated the fact so many fans invested their emotions in my performance.

My training took seven years. I didn’t learn how to make sushi for the first three years. I only got two days off a month, and slept on the restaurant floor. But I loved the job. I’d go to the fish market every morning. I got to open the restaurant and see the customers. I’d watch my mentor making sushi and would copy him under the table, practising with my fingers.

We need to have mentors. I think I've always been pretty shameless about seeking out people much smarter and much more experienced than me from the very beginning. Michael Seibel and other people. And the more successful I got, the more leaders I started seeking out, whether it was investors, or Sheryl Sandberg at Facebook, or I got the opportunity to spend time with Warren Buffett and he became a close mentor of mine.

He gave me freedom at the age of 11, and told me that [I should] chase my dreams, but make sure you do not find short cuts. The path might be difficult, but don't give up, and I have simply followed his instructions. […] Every time I have done something special [and] showed my bat, it was [for] my father.