My wife, my children, my friends, myself. I’m my own strongest critic. I am much tougher on myself than anybody I know, consistently.

I surround myself with brilliant people who are wise and whose advice I can lean on at every possible moment. The Genome Project is a wonderful team effort. It’s not my project, this is a project that involves close to 1,000 scientists at institutions all over the world. The United States is taking a larger role than any other country, but many other countries are participating. In the U.S. we have a large number of genome centers. We have experts in almost every area. I have advisors who are willing to give up their time and energy to making sure we get there responsibly. It is a heavy load of responsibility, but I can share that load with people who are every bit as committed to the future of this endeavor as I am.

My mother made the same brilliant impression upon my childhood's eye. She shone for me like the Evening Star. I loved her dearly—but at a distance. My nurse was my confidante. Mrs. Everest it was who looked after me and tended all my wants. It was to her I poured out my many troubles, both now and in my schooldays.

Anyhow, I talked it over with my mother, and she said, “Well, if that’s what you want, go right ahead.” She was a wonderful woman. And so I did.

The challenge of a big, over-arching vision is that it's hard to know where to start. And your biggest opportunity will change from year to year. Technology changes. Competition changes. You change. My advice: Just start. Find a single unmet need that nudges the world closer to where you believe it's going. And if you hit a dead end, pivot.

Obvious I give out my own books fairly often: The Startup View , The Alliance . Recently I’ve been giving out another book of friend of mine, Joshua Cooper Ramos, The Seventh Sense .

Our culture lionizes entrepreneurs who navigate daring switchbacks in their career. Steve Jobs was admired not just for Apple, but also his detour to found Pixar. Elon Musk is revered for helming Tesla AND SpaceX. But don't be distracted by other people's winding paths. I believe you should celebrate your single-mindedness, and stick to your own overarching idea — for as long as it holds your own fascination. In my experience, that could last your entire career.

This is going to sound a little strange, but my trainer started recommending that I add moringa leaf powder to my tea. That’s actually added a rich antioxidant, anti inflammatory and a little bit more substance such that drinking tea now feels a little bit like a snack and is super healthy.