Who do you turn to when you need advice?

I surround myself with brilliant people who are wise and whose advice I can lean on at every possible moment. The Genome Project is a wonderful team effort. It’s not my project, this is a project that involves close to 1,000 scientists at institutions all over the world. The United States is taking a larger role than any other country, but many other countries are participating. In the U.S. we have a large number of genome centers. We have experts in almost every area. I have advisors who are willing to give up their time and energy to making sure we get there responsibly. It is a heavy load of responsibility, but I can share that load with people who are every bit as committed to the future of this endeavor as I am.

Anyhow, I talked it over with my mother, and she said, “Well, if that’s what you want, go right ahead.” She was a wonderful woman. And so I did.

People refer to the ‘LMB culture’ as the thing, one of the things, that makes it special. It’s an attention to people who are willing to tackle very big problems. I mean problems that are so big that you couldn’t just solve it in a grant. The kind of problem that you could devote your life to. I was very fortunate in having mentors of Fred Sanger and César Milstein who exercised a kind of very benign mentorship but encouraged us to think big.