I question everything. This is also my greatest intellectual habit.

Often, what happens in science is you got a problem and you solve it, and then there’s not much else to do and you have to move on. But the ribosome turned out to be a rather rich gold mine. Perhaps I’m a little intellectually lazy and feel like, “Why should I bother thinking about something else?” Maybe at some point, I should have thought, “I should do something different.”

Ironically, though, this is also the purchase in which I made my biggest mistake - of a kind, however, never recognized on financial statements. We paid $600 million in 1989 for Gillette preferred shares that were convertible into 48 million (split-adjusted) common shares. Taking an alternative route with the $600 million, I probably could have purchased 60 million shares of common from the company. The market on the common was then about $10.50, and given that this would have been a huge private placement carrying important restrictions, I probably could have bought the stock at a discount of at least 5%. I can't be sure about this, but it's likely that Gillette's management would have been just as happy to have Berkshire opt for common. But I was far too clever to do that.

Overthinking. I tend to conflate the amount of time spent on something with how good it is. Sometimes intuition is better than proof, and gut instinct better than hours of “work.”

Well, it certainly influences my manner of writing, because I always see Darwin as a model of the act of explanation and of argument; the morality, the ethics of explanation, maybe.

Writers we think are all wrong and want to read anyway come in two kinds: those who are good writers and bad thinkers — Christopher Hitchens, Norman Podhoretz, and Gore Vidal, each in his terribly different way, are instances of that — and those who may not be original stylists but who we admire for trying to be better thinkers than they were before, stumbling toward truth from a starting place very different from the one we happened to inherit. I disagree, for instance, with David Frum about almost everything, from Iraq to the legacy of Pierre Trudeau in our native Canada, but never doubt his integrity or desire to tell the truth about the world.