How has a setback or failure set you up for later success?

It was a brilliant idea: You have no responsibility to live up to what other people think you ought to accomplish.  I have no responsibility to be like they expect me to be.

I got quite nice results in my one-question studies, but never wrote up any of the work, because I had set myself impossible standards: in order not to pollute the literature, I wanted to report only findings that I had replicated in detail at least once, and the replications were never quite perfect. I realized only gradually that my aspirations demanded more statistical power and therefore much larger samples than I was intuitively inclined to run. This observation also came in handy some time later.

So Cambridge rejected me. Quite rightly, although at the time I thought it was a little churlish. So, I had to do it without any university training. ... and I began to realize that there were probably a lot more of these things, and that if you find these things, you get a position in the ladder which you can’t get to unless you have either got an education or something else. So by finding important things, you immediately get into the game, which you’d been excluded from otherwise.

At first the research did not seem to be particularly interesting – I carried out a systematic search for processes that might destroy the CFCs in the lower atmosphere, but nothing appeared to affect them. We knew, however, that they would eventually drift to sufficiently high altitudes to be destroyed by solar radiation. The question was not only what destroys them, but more importantly, what the consequences are.

In fact, what I usually say to people, “Probably some of the most successful scientists are the ones that know how to deal with failure well.” Because it’s easy to feel good when you succeed. That’s an easy thing. But you’re probably going to fail in science a lot more than you succeed, so you really have to learn how to deal with it and not let it beat you.