What is the hardest thing that has happened to you, and what did you carry out of it?

Prisoner of War! That is the least unfortunate kind of prisoner to be, but it is nevertheless a melancholy state. You are in the power of your enemy. You owe your life to his humanity, and your daily bread to his compassion. You must obey his orders, go where he tells you, stay where you are bid, await his pleasure, possess your soul in patience. Meanwhile the war is going on, great events are in progress, fine opportunities for action and adventure are slipping away. Also the days are very long. Hours crawl like paralytic centipedes. Nothing amuses you. Reading is difficult; writing impossible. Life is one long boredom from dawn till slumber. Moreover, the whole atmosphere of prison, even the most easy and best regulated prison, is odious. Companions in this kind of misfortune quarrel about trifles and get the least possible pleasure from each other's society. If you have never been under restraint before and never known what it was to be a captive, you feel a sense of constant humiliation in being confined to a narrow space, fenced in by railings and wire, watched by armed men, and webbed about with a tangle of regulations and restrictions. I certainly hated every minute of my captivity more than I have ever hated any other period in my whole life. ... Therefore in after years, when I was Home Secretary and had all the prisons of England in my charge, I did my utmost consistent with public policy to introduce some sort of variety and indulgence into the life of their inmates, to give to educated minds books to feed on

I don’t think I could. Of course I’m saying this on American soil. I’m facing a few more months of work in this city, but at the end of it, I will be returning to South Africa. I would like to believe that if for some reason the situation deteriorated to the point where I was told, “If you leave South Africa, you can never come back,” I’d stay there. There were periods in my life when I could have been seduced away. I am incredibly fortunate that the government took away my passport at the point when I was most open to seduction. With my passport gone, I could have left on a one-way ticket. But the issue was so starkly highlighted that I had no problem in saying, “No.”

The two alternatives left then to us were either to emigrate to the United States, or to pursue some activity that needed neither support nor connection with the outside Aryan world where we lived. My family chose this second alternative. I then decided to build a small research unit at home and installed it in my bedroom. My inspiration was a 1934 article by Viktor Hamburger reporting on the effects of limb extirpation in chick embryos. My project had barely started when Giuseppe Levi, who had escaped from Belgium invaded by Nazis, returned to Turin and joined me, thus becoming, to my great pride, my first and only assistant.

If you really want to make a difference, whether it’s in helping other people, or whether it’s in fighting for your country, or whether it’s in the political arena, or journalism, or physics, you’ve got to persevere. You’ve got to understand that there are going to be some enormous bumps in the road.

I was the first black in that particular league. And, we played in a town called Hagerstown, Maryland. ... I said to myself — and this is why Piper Davis came in — in my mind, “Hey, whatever they call you, they can’t touch you. Don’t talk back.”

After the war — I was 15 when I entered the camp, I was 16 when I left it, and all of a sudden you become an orphan and you have no one. I had a little sister and I knew, with my mother the first night, that they were swept away by fire. My older sisters I discovered by accident after the war in Paris, where I was in an orphanage. But to be an orphan — you can become an orphan at 50, you are still an orphan. Very often I think of my father and my mother. At any important moment in my life, they are there, thinking, “What an injustice.”

everyone saw me as a victim of a terrible illness. But what happened to my body was far less frightening than what happened to my soul. The stroke wiped out my faith. It took me so far from my guru that I felt my oxygen cord had been cut. ... I couldn't put the two together. Then I thought, maybe the stroke is a form of grace, and I hunted for that: how could the stroke be seen as grace? ... The stroke was giving me lessons, advanced lessons. ... It brought me into my soul, and that's grace.

And I spent four years at a boarding school in the country, probably a rather abusive boarding school, and seeing very little of my parents, and that was a very bad time for me. A bad and almost a mad time. ... I think that some sort of trust, and ability for closeness, may have been compromised. And I think I’ve perhaps, to some extent, sort of kept a distance since that time, although this is not a distance I feel with my patients or my students.

When Milton's Satan stood in the pit of hell and raged at heaven, he was merely a trifle miffed compared to how I felt on that day. I felt totally alone, with the world receding away from me in every direction, and you could have used my anger to weld steel. Only my family and the fact I had fans in the medical profession, who were able to give me useful advice, got me through that moment.

And in the end they robbed us, but they did let us go. But I think that that was a very useful lesson early in my journalism career, that things can go very badly wrong. At one moment you can be going down a road and things are perfect, and the next moment you’ve got some drunk soldiers who just may kill you. That fear that I felt when they were holding us for maybe 45 minutes or so in the jungle, that has never entirely left me.

And into the darkness I said, “What happened?” and a woman’s voice said, “It was a car bomb,” and I collapsed into darkness again, but with a sense of euphoria. I’d survived.

Writing became a therapy. First of all, it meant I was reconstructing my own existence. It was also an act of defiance. I wasn’t supposed to write. ... I evolved all kinds of mental exercises, even went back to those subjects which I said I hated in school, in particular mathematics. ... You know, anything to keep the mind alive.

But the satisfactions of compensation are notoriously fleeting. There is no saving grace in being confined to an iron suit, cold and unforgiving. The pleasures of mental agility are much overstated, inevitably—as it now appears to me—by those not exclusively dependent upon them. Much the same can be said of well-meaning encouragements to find nonphysical compensations for physical inadequacy. That way lies futility. Loss is loss, and nothing is gained by calling it by a nicer name. My nights are intriguing; but I could do without them.

Thank God I found sobriety. I could sustain myself with my work, my reading, the movies, my friends. And walking, walking, walking. Of all the purposes of education, I think the most useful is this: It prepares you to keep yourself entertained. It gives you a better chance of an interesting job. ... I can't remember the last time I felt bored. I can't eat, drink or talk, and yet I have so many other resources to keep myself entertained. I think I must be a case study.

Deprivation of the ability to speak is more like an attack of impotence, or the amputation of part of the personality. To a great degree, in public and private, I “was” my voice. All the rituals and etiquette of conversation, from clearing the throat in preparation for the telling of an extremely long and taxing joke to (in younger days) trying to make my proposals more persuasive as I sank the tone by a strategic octave of shame, were innate and essential to me. I have never been able to sing, but I could once recite poetry and quote prose and was sometimes even asked to do so.

Look, life is pretty dreadful most of the time. Even in the country that's so pretty with the flowers and leaves and sunshine. And I was abandoned when he died! I'm alone. I feel like an old bubba. And I'm not kind all of the time, I'm not nice all the time.

I was raised by a heroic single mom, wonderful grandparents -- made incredible sacrifices for me. … But I sure wish I had had a father who was not only present, but involved. Didn't know my dad. And so my whole life, I've tried to be for Michelle and my girls what my father was not for my mother and me. … I want to be a better father, a better husband, a better man.

I try but I can’t think of a single aspect of having cancer, start to finish, that isn’t an act in a pantomime in which my participation is guaranteed however I believe I choose to play each scene. I have been given this role. (There, see? Instant victim.) I have no choice but to perform and to be embarrassed to death. I wish you long life.

I had two options. One was to remain silent and wait to be killed. And the second was to speak up and then be killed. I chose the second one. I decided to speak up.

One thing, it's too big a subject and I want to talk about it on paper if I talk about it at all. But I can say this much, because I thought the life that my father and mother would have had together was cut short and something of what they might have achieved I hope that I'm achieving in my work.