Failure & regret

What is the hardest thing that has happened to you, and what did you carry out of it?

40 answers answered between 1930 and 2026

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Public figures who have answered a question like this elsewhere. Quoted from the source shown, not written for FLAPSS.

Rita Levi-Montalcini Neurobiologist; Nobel laureate in Physiology or Medicine, 1986
The two alternatives left then to us were either to emigrate to the United States, or to pursue some activity that needed neither support nor connection with the outside Aryan world where we lived. My family chose this second alternative. I then decided to build a small research unit at home and installed it in my bedroom. My inspiration was a 1934 article by Viktor Hamburger reporting on the effects of limb extirpation in chick embryos. My project had barely started when Giuseppe Levi, who had escaped from Belgium invaded by Nazis, returned to Turin and joined me, thus becoming, to my great pride, my first and only assistant.
Recorded Laureate-written autobiography for Les Prix Nobel, Nobel Prize Outreach, 1 December 1986 source ↗
George H. W. Bush 41st President of the United States, 1989–1993
If you really want to make a difference, whether it’s in helping other people, or whether it’s in fighting for your country, or whether it’s in the political arena, or journalism, or physics, you’ve got to persevere. You’ve got to understand that there are going to be some enormous bumps in the road.
Recorded Academy of Achievement interview, Williamsburg, Virginia, 2 June 1995 source ↗
Desmond Tutu Anglican Archbishop of Cape Town; chair of South Africa’s Truth and Reconciliation Commission; Nobel Peace Prize, 1984
We received death threats, yes, but you see when you are in a struggle, there are going to have to be casualties, and why should you be exempt? But I often said, “Look, here, God, if I’m doing your work, then you jolly well are going to have to look after me!” And God did God’s stuff.
Recorded Academy of Achievement recorded interview, American Academy of Achievement, 12 June 2004 source ↗
Albie Sachs Anti-apartheid lawyer; Justice of the Constitutional Court of South Africa
And into the darkness I said, “What happened?” and a woman’s voice said, “It was a car bomb,” and I collapsed into darkness again, but with a sense of euphoria. I’d survived.
Recorded Academy of Achievement interview, 3 July 2009 source ↗
Wole Soyinka Playwright, poet and novelist; Nobel laureate in Literature, 1986
Writing became a therapy. First of all, it meant I was reconstructing my own existence. It was also an act of defiance. I wasn’t supposed to write. ... I evolved all kinds of mental exercises, even went back to those subjects which I said I hated in school, in particular mathematics. ... You know, anything to keep the mind alive.
Recorded Academy of Achievement interview, 3 July 2009 source ↗
Maurice Sendak Children's author and illustrator
Look, life is pretty dreadful most of the time. Even in the country that's so pretty with the flowers and leaves and sunshine. And I was abandoned when he died! I'm alone. I feel like an old bubba. And I'm not kind all of the time, I'm not nice all the time.
Recorded Emma Brockes, The Observer, at his home in Connecticut — his last Guardian interview, The Guardian, 2 October 2011 source ↗
Clive James Critic, essayist, poet and broadcaster
One thing, it's too big a subject and I want to talk about it on paper if I talk about it at all. But I can say this much, because I thought the life that my father and mother would have had together was cut short and something of what they might have achieved I hope that I'm achieving in my work.
Recorded Philip Williams, 7.30, ABC, ABC News, 20 August 2015 source ↗
Tu Youyou Pharmaceutical chemist; Nobel laureate in Physiology or Medicine, 2015
I unfortunately contracted tuberculosis at the age of sixteen and had to take a two-year break and receive treatment at home before I resumed my study at the private Ningbo Xiaoshi High School (1948–1950) and Ningbo High School (1950–1951). This experience led me to make a decision to choose medical research for my advanced education and career – if I could learn and have (medical) skills, I could not only keep myself healthy but also cure many other patients.
Recorded Laureate-written autobiography for Les Prix Nobel, Nobel Prize Outreach, 1 December 2015 source ↗
Nobu Matsuhisa Chef and restaurateur
I moved to Argentina, then back to Tokyo and then to Anchorage, in Alaska, where I ran a restaurant. After 50 days the restaurant burnt down – an electrical fire. I lost my dream. I lost my money. I lost my passion. I thought about suicide, but thinking of my family and my kids made me realise I had to wake up.
Recorded The Observer / The Guardian, 12 April 2025 source ↗

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