There were so many needs for us to continue to work for freedom, because I didn’t think that we should have to be treated in the way we were, just for the sake of white supremacy, because it was designed to make them feel superior, and us feel inferior. That was the whole plan of racially enforced segregation.

It is in human nature to contain both the positive and the negative. However, it is also within human capability to work to reinforce the positive and to minimize or neutralize the negative.

I was forced to think very hard about what it meant to be me, what it means to be a person who is only a brain. Pascal's 'thinking reed' really does capture it, because I'm just a bunch of dead muscles thinking.

When I was a child the mailman came once a day. Now the mail arrives every moment. I used to believe it was preposterous that people could fall in love online. Now I see that all relationships are virtual, even those that take place in person. Whether we use our bodies or a keyboard, it all comes down to two minds crying out from their solitude.

And I spent four years at a boarding school in the country, probably a rather abusive boarding school, and seeing very little of my parents, and that was a very bad time for me. A bad and almost a mad time. ... I think that some sort of trust, and ability for closeness, may have been compromised. And I think I’ve perhaps, to some extent, sort of kept a distance since that time, although this is not a distance I feel with my patients or my students.

And now, weak, short of breath, my once-firm muscles melted away by cancer, I find my thoughts, increasingly, not on the supernatural or spiritual, but on what is meant by living a good and worthwhile life — achieving a sense of peace within oneself. I find my thoughts drifting to the Sabbath, the day of rest, the seventh day of the week, and perhaps the seventh day of one’s life as well, when one can feel that one’s work is done, and one may, in good conscience, rest.

I cannot pretend I am without fear. But my predominant feeling is one of gratitude. I have loved and been loved; I have been given much and I have given something in return; I have read and traveled and thought and written. I have had an intercourse with the world, the special intercourse of writers and readers. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure.

The first biography I read — I think the first scientific biography — was Madame Curie . And my mother, who was a surgeon, worked at the Marie Curie Hospital. She’d met Marie Curie, who was one of her great heroines. And reading the book, I think, was the first portrait of a scientist and the romance of a scientific life.

I feel a sudden clear focus and perspective. There is no time for anything inessential. I must focus on myself, my work and my friends. I shall no longer look at “NewsHour” every night. I shall no longer pay any attention to politics or arguments about global warming. This is not indifference but detachment — I still care deeply about the Middle East, about global warming, about growing inequality, but these are no longer my business; they belong to the future. I rejoice when I meet gifted young people — even the one who biopsied and diagnosed my metastases. I feel the future is in good hands.

On the contrary, I feel intensely alive, and I want and hope in the time that remains to deepen my friendships, to say farewell to those I love, to write more, to travel if I have the strength, to achieve new levels of understanding and insight. This will involve audacity, clarity and plain speaking; trying to straighten my accounts with the world. But there will be time, too, for some fun (and even some silliness, as well).