What is the most important lesson life has taught you?

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Recorded Terry Pratchett said elsewhere, not written here
It occurred to me that at one point it was like I had two diseases – one was Alzheimer's and the other was knowing I had Alzheimer's. There were times when I thought I'd have been much happier not knowing, just accepting that I'd lost brain cells and one day they'd probably grow back or whatever. It is better to know, though, and better for it to be known, because it has got people talking, which I rather think was what I had in mind.

Written for the Alzheimer's Society in 2008; reprinted by the Observer in the week of his death, The Guardian, 2008 source ↗

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Christiane Nüsslein-Volhard Developmental biologist; Nobel laureate in Physiology or Medicine, 1995
Not really. I thought that getting the Nobel Prize was a big interruption in my career, I thought and it was very distracting. It takes a lot of time you know, it just takes time to be honoured, you have to travel and you have to give speeches of things you have, oh it’s so often that you get bored to tears when you hear your own voice. And it’s really taking a lot of your time and there’s no way that during this time you can start something new, I mean you just profit from what you’ve done and there is no time to develop new ideas.
Recorded Marika Griehsel, Interview at the 53rd Lindau Nobel Laureate Meeting, 30 June–4 July 2003, Nobel Prize Outreach, 1 July 2003 source ↗

More from Terry Pratchett

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Question What is the hardest thing that has happened to you, and what did you carry out of it? Failure & regret
When Milton's Satan stood in the pit of hell and raged at heaven, he was merely a trifle miffed compared to how I felt on that day. I felt totally alone, with the world receding away from me in every direction, and you could have used my anger to weld steel. Only my family and the fact I had fans in the medical profession, who were able to give me useful advice, got me through that moment.
Recorded Written for the Alzheimer's Society in 2008; reprinted by the Observer in the week of his death, The Guardian, 2008 source ↗
Question What scares you about getting older? Time & hindsight
When my father was in his terminal year, I discussed death with him. I recall very clearly his relief that the cancer that was taking him was at least allowing him "all his marbles". Dementia in its varied forms is not like cancer. Dad saw the cancer in his pancreas as an invader. But Alzheimer's is me, unwinding, losing trust in myself, a butt of my own jokes and on bad days capable of playing hunt the slipper by myself and losing. You can't battle it, you can't be a plucky "survivor". It steals you from yourself. And I'm 60; that's supposed to be the new 40.
Recorded Written for the Alzheimer's Society in 2008; reprinted by the Observer in the week of his death, The Guardian, 2008 source ↗
Question Has knowing that you will die changed how you live? Death & what remains
Let us consider me as a test case. As I have said, I would like to die peacefully with Thomas Tallis on my iPod before the disease takes me over and I hope that will not be for quite some time to come, because if I knew that I could die at any time I wanted, then suddenly every day would be as precious as a million pounds. If I knew that I could die, I would live. My life, my death, my choice.
Recorded Edited extract from the Richard Dimbleby Lecture, Shaking Hands With Death, broadcast on BBC1 on 1 February 2010, The Guardian, 2 February 2010 source ↗
Question How would you like to die? Death & what remains
I remember what George said and vowed that rather than let Alzheimer's take me, I would take it. I would live my life as ever to the full and die, before the disease mounted its last attack, in my own home, in a chair on the lawn, with a brandy in my hand to wash down whatever modern version of the "Brompton cocktail" some helpful medic could supply. And with Thomas Tallis on my iPod, I would shake hands with Death.
Recorded Edited extract from the Richard Dimbleby Lecture, Shaking Hands With Death, Royal College of Physicians, broadcast on BBC1 on 1 February 2010, The Guardian, 2 February 2010 source ↗
Question Are you afraid of death? Death & what remains
Did the Victorians fear death? As Death says in one of my own books, most men don't fear death, they fear those things – the knife, the shipwreck, the illness, the bomb – that proceed, by micro seconds if you're lucky and many years if you're not, the moment of death.
Recorded Edited extract from the Richard Dimbleby Lecture, Shaking Hands With Death, broadcast on BBC1 on 1 February 2010, The Guardian, 2 February 2010 source ↗

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