And some of the things that we saw in the ’80s, really, they were failures, because patients died. But they allowed us to diagnose the systems’ problems and say, “This is where we need a community health worker system. This is where we need to make sure patients have food support while they’re getting these medicines,” et cetera. So those are examples of tragedies that certainly lead to — not just personal epiphanies — but collective epiphanies, where you say, “You know what? We can do this better if we have the system fixed.”

So Cambridge rejected me. Quite rightly, although at the time I thought it was a little churlish. So, I had to do it without any university training. ... and I began to realize that there were probably a lot more of these things, and that if you find these things, you get a position in the ladder which you can’t get to unless you have either got an education or something else. So by finding important things, you immediately get into the game, which you’d been excluded from otherwise.

Failure is the most likely outcome of entrepreneurship. Hence there is absolutely nothing wrong with failure. It is the default outcome. Success on the other hand is rare and unpredictable. Very few find it. However what can help entrepreneurs succeed is when an ecosystem learns from failure.

They’re not failures, you try something and it doesn’t work, and some people, you know, get fed up with this, and I’ve known some of my friends and colleagues who have just decided to give up science because they can’t stand it, but I’ve always decided, you know, if it doesn’t work, forget it and start planning the next experiment, and that’s always exciting.

One of my favorite lessons is best summed up in the words of an old Athabascan Indian who told me, “There are many hard things in life, but there is only one sad thing, and that is giving up.”

But whenever you do find something — maybe it’s not as passionate for you as dog mushing has been for me — but the fact that you have any interest, that is what you should go with.