Myself, I love the imagery of struggle. I sometimes wish I were suffering in a good cause, or risking my life for the good of others, instead of just being a gravely endangered patient. Allow me to inform you, though, that when you sit in a room with a set of other finalists, and kindly people bring a huge transparent bag of poison and plug it into your arm, and you either read or don’t read a book while the venom sack gradually empties itself into your system, the image of the ardent soldier or revolutionary is the very last one that will occur to you. You feel swamped with passivity and impotence: dissolving in powerlessness like a sugar lump in water.

I have generally had few setbacks and few obstacles. I have been very fortunate in that things have been handed to me rather than my going out after them. There are a few roads that I didn’t take that I maybe could have. When I was a graduate student, maybe a second-year graduate student, I worked frequently at the Illinois State Library in Springfield, and one day, the director of that library called me into his office and said, “I have some news to tell you that is still very hush-hush, but I’m resigning from this job. I’m going to the Chicago Historical Society, and I’m going to recommend that you be appointed in my place.

But, of course, we had one problem that the modern mountaineer doesn’t have. That is, this psychological barrier. We really didn’t know whether it was humanly possible to reach the top of Mt. Everest. And even using oxygen as we were, if we did get to the top, we weren’t at all sure whether we wouldn’t drop dead or something of that nature. All the physiologists had warned us that the altitude at the summit of Everest was a very marginal altitude and might be extremely dangerous. So, one had this feeling in your mind all the time that maybe you were pushing things a bit beyond what humans were meant to do and you couldn’t ignore that feeling. But, because of strong motivation, you keep plugging on and you seem to be going okay and nothing seems to be going wrong, so you persist. And we persisted, of course, and ultimately, set foot on the summit.

At Pixar when we were making Toy Story, there came a time when we were forced to admit that the story wasn't great. It just wasn't great. We stopped production for five months.... We paid them all to twiddle their thumbs while the team perfected the story into what became Toy Story. And if they hadn't had the courage to stop, there would have never been a Toy Story the way it is, and there probably would have never been a Pixar.

I think that loss of speech, and of understanding of speech, and of understanding of writing, and of coherent writing – these losses will amount to the loss of my mind. I know what this feels like and it has no insides, no internal echo. Mind means talking to oneself. There wouldn't be any secret mind surviving in me.

It's not possible to get any distance from my project: being alive. Objectively, from the outside you might say, my life is terrible, unbelievable. And it's true, I hate this. I hate the way I am at the moment. But there is no objective view, I am here, in it, and there is nothing else, and this fact brings with it many things that make it of course easier. And beyond that there are many other things to think about.

The mystery of summoning up words. Where are they in the mind, in the brain? They appear to be an agency from nowhere. They exist somewhere in our ground or in our air. They come from unknown darkness. From a place we normally don't think about.

It is a very rare affliction. A GP would expect to meet it once in a career and this form of brain cancer is unpredictable and dangerous. Usually, this tumour might give you only a two-year span since its discovery. I have had two operations and one course of radiotherapy and now three chemotherapies (one currently starting). My death is, in a sense, imminent. I say to myself: I am dying. Something in my head is hurrying to kill me.