When I started getting my first fan letters, I made a point to try to respond to every single one. The wins always felt that much more special because I knew I was making so many people happy. And losses hurt that much worse because I truly was invested in not wanting to disappoint those who supported my side. But more than anything, I always appreciated the fact so many fans invested their emotions in my performance.

My science family came from all over the world, and members were of varied backgrounds, cultures, and abilities. The diversity in this "small world" I worked in daily provided the most stimulating environment, with many challenges and much optimism. Over the years, my research group has had close to 150 graduate students, postdoctoral fellows, and visiting associates. Many of them are now in leading academic, industrial and governmental positions. Working with such minds in a village of science has been the most rewarding experience – Caltech was the right place for me.

So I decided I was going to invest my time. I spent Monday through Thursday at Frito-Lay, commuting from New York to Texas. Then Friday, Saturday and Sunday, I did my regular job in New York. It was an incredible commitment of time but it was an amazing developmental experience. It was challenging, broadening, and helped me reach the position I have today.

Remember, if you sit at your desk for 15 or 20 years, every day, not ­counting weekends, it changes you. It just does. It may not improve your temper, but it fixes something else. It makes you more free.

I moved to Argentina, then back to Tokyo and then to Anchorage, in Alaska, where I ran a restaurant. After 50 days the restaurant burnt down – an electrical fire. I lost my dream. I lost my money. I lost my passion. I thought about suicide, but thinking of my family and my kids made me realise I had to wake up.