It was a brilliant idea: You have no responsibility to live up to what other people think you ought to accomplish.  I have no responsibility to be like they expect me to be.

I don’t know. That’s a terrible answer I realise, and everyone wants a nice straight forward answer. I think everyone, all scientists, have these kind of wacky ideas along the way, and some of them work and some of them don’t work. And this was one that, you know, came and was successful and went forward, and again it sounds obvious to say we were lucky – but we were lucky, you know, there’s way more ideas fail than ever succeed, and this was one that, you know, we were very excited about at the beginning, we thought it had a very low probability of success, but it took off, and it took off like gangbusters. That was wonderful to see.

In fact, what I usually say to people, “Probably some of the most successful scientists are the ones that know how to deal with failure well.” Because it’s easy to feel good when you succeed. That’s an easy thing. But you’re probably going to fail in science a lot more than you succeed, so you really have to learn how to deal with it and not let it beat you.

No one has a 5.0 in real life. In fact, when you finish school, the whole notion of a GPA just goes away. When you're in school, every little mistake is a permanent crack in your windshield. But in the real world, if you're not swerving around and hitting the guard rails every now and then, you're not going fast enough. Your biggest risk isn't failing, it's getting too comfortable.

Nothing in the world is worth having or worth doing unless it means effort, pain, difficulty…I have never in my life envied a human being who led an easy life. I have envied a great many people who led difficult lives and led them well.

Shame on the man of cultivated taste who permits refinement to develop into a fastidiousness that unfits him for doing the rough work of a workaday world!

Nothing in this world is worth having or worth doing unless it means effort, pain, difficulty. No kind of life is worth leading if it is always an easy life. I know that your life is hard; I know that your work is hard; and hardest of all for those of you who have the highest trained consciences, and who therefore always feel how much you ought to do. I know your work is hard, and that is why I congratulate you with all my heart. I have never in my life envied a human being who led an easy life; I have envied a great many people who led difficult lives and led them well.

I wish to preach, not the doctrine of ignoble ease, but the doctrine of the strenuous life, the life of toil and effort, of labor and strife; to preach that highest form of success which comes, not to the man who desires mere easy peace, but to the man who does not shrink from danger, from hardship, or from bitter toil, and who out of these wins the splendid ultimate triumph.

Far better it is to dare mighty things, to win glorious triumphs, even though checkered by failure, than to take rank with those poor spirits who neither enjoy much nor suffer much, because they live in the gray twilight that knows not victory nor defeat.

The most important single ingredient in the formula of success is knowing how to get along with people.