Working at the hospital, I found that my surgical skills were not as good as I expected. One time it took me two hours to do a surgical operation which could have been completed in 30 minutes by other surgeons. My supervisors were very tough on new residents like me, and I lost confidence in my ability.

No. I mean if you fail 70 percent of the time, you had a great year. You're dealing with failure seven out of ten times as a hitter.

No, no. Well, you know, biology is such a complex system. It’s totally different from the engineering. We cannot design. Many people tried to find the therapy for cancer, but all failed. And myself, I never expected my research, working on the immune system, would lead to the cancer therapy. But, in a sense, I’m very fortunate that I also thought about it. You know, you have to try many things and if you’re lucky you can hit, but you have to pursue. That’s my feeling.

The Godfather was a very unappreciated movie when we were making it. They were very unhappy with it. They didn't like the cast. They didn't like the way I was shooting it. I was always on the verge of getting fired. So it was an extremely nightmarish experience. I had two little kids, and the third one was born during that. We lived in a little apartment, and I was basically frightened that they didn't like it. They had as much as said that, so when it was all over I wasn't at all confident that it was going to be successful, and that I'd ever get another job.

Finding gratitude and appreciation is key to resilience. People who take the time to list things they are grateful for are happier and healthier. It turns out that counting your blessings can actually increase your blessings. My New Year's resolution this year is to write down three moments of joy before I go to bed each night. This simple practice has changed my life. Because no matter what happens each day, I go to sleep thinking of something cheerful.