As I was lazy and rarely did my homework, I finished high school with a rather mediocre exam. I almost did not pass in English language. Recently, my previous teachers allowed me to see their report on my high school performances, which included the following statements: Despite the fact that her talents are rather equally spread among many areas of knowledge, her performances are rather different depending on the distribution of her interests. Thus, with her strong display of self will she can be decidedly lazy in some topics over years, while in her areas of interests she performs to a degree far extending that required for normal school purposes.

I tried for a Ph.D. scholarship to work with Cedric Mims, but was told to apply again later because he already had a "scholar" and would take only one student at a time. … The following week a job in the Department of Experimental Pathology at the Moredun was advertized in Nature. We sailed for Britain in early 1967, on a very slow and cheap ship.

I don’t know. That’s a terrible answer I realise, and everyone wants a nice straight forward answer. I think everyone, all scientists, have these kind of wacky ideas along the way, and some of them work and some of them don’t work. And this was one that, you know, came and was successful and went forward, and again it sounds obvious to say we were lucky – but we were lucky, you know, there’s way more ideas fail than ever succeed, and this was one that, you know, we were very excited about at the beginning, we thought it had a very low probability of success, but it took off, and it took off like gangbusters. That was wonderful to see.

As hard as it's been to come to this decision, I am at peace with it. I have no regrets. I was not supposed to be here in the first place, remember? Not many people believed in my talent and my abilities, yet I found a way to persevere, to prove them (and sometimes myself!) wrong.

However, it was very natural that a failed surgeon with little experience in molecular biology had a hard time finding a position. A turning point came when I got a fax from Thomas Innerarity at the Gladstone Institute of Cardiovascular Diseases in San Francisco. After a short telephone conversation, Tom was brave enough to give me a postdoctoral position in his lab! Working at Gladstone was one of the best decisions I ever made in my life.

Well, I will bring this technology to clinics. I really want to help as many patients as possible. As you may know, I started my career as a surgeon 25 years ago. But it turned out that I am not talented as a surgeon

Running CiRA with some 250 staff, I have come to spend less time discussing their data with my colleagues and students, and have been absorbed by my duties as the "chief executive officer" of CiRA, including devising strategies to advance both basic and applied research and to obtain sufficient funding. Anxious about the lack of financial resources for the future to allow us to continue hiring research support staffers, I even ran the full Kyoto Marathon in 2012 to raise online donations from the public. It was hard but helped us raise more than 10 million yen.

I was born in Osaka, Japan. It was 45 years ago. My father has a small factory in Osaka, and we lived next to his factory

my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

So I think failure is important in my career.