And this is where, a couple of years before I had become CEO, I had read this book by Carol Dweck out of Stanford [University] called “Mindset,” which was more in relation to my kids. And the simple concept in that book, which I loved a lot, was it's better to be a learn-it-all even if the know-it-all has more innate capability, because the learn-it-all ultimately will do better. And I said, well, that applies to CEOs. That applies to companies made up of people. And I said: What if we introduce that as the meme to have the cultural dialogue at Microsoft?

All right, I'm going to give you two, because they're kind of categories to it. I'd say the first one underneath this health and human performance realm, Diagnosis and Treatment of Movement Impairment Syndromes. It's a Shirley Sahrmann book that I think is landmark. I mean it's decades old, super impactful. Kind of reads like stereo instructions, so you're going to go through a page at a time. But Sahrmann is still a practicing physical therapist at Wash U in St. Louis.

In Ge Hong's A Handbook of Prescriptions for Emergencies (肘后备急方), I noticed one sentence "A handful of Qinghao immersed in two liters of water, wring out the juice and drink it all" (青蒿一握, 以水二升渍, 绞取汁, 尽服之) when Qinghao was mentioned for alleviating malaria fevers. Most herbs were typically boiled in water and made into a decoction before taken by the patients. This unique way of using Qinghao gave me the idea that heating during extraction might have destroyed the active components and the high temperature might need to be avoided in order to preserve the herb's activity.

That’s sort of pushed Mistakes Were Made (But Not by Me) into the now number three spot, just ahead probably of Surely You’re Joking, Mr. Feynman! It’s weird, isn’t it? It says something about us, the books we like to give people, doesn’t it? You thanked Michael Pollan at the end of your interview or maybe it was somewhere in the midst of it, but I thought it was at the end of the interview for writing the book that he did because you said it was the book you wanted to read and that you wish you could have written, but you’re no slouch yourself when it comes to writing books. Is there anything that if Michael hadn’t had done that and you would have been writing that book in addition to all the stuff we’ve talked about today, is there anything else that you would have included in that book that wasn’t included? He’s a tough act to follow.

However, it was very natural that a failed surgeon with little experience in molecular biology had a hard time finding a position. A turning point came when I got a fax from Thomas Innerarity at the Gladstone Institute of Cardiovascular Diseases in San Francisco. After a short telephone conversation, Tom was brave enough to give me a postdoctoral position in his lab! Working at Gladstone was one of the best decisions I ever made in my life.

I got very interested in so-called “knockout mouse” technology. Knockout mouse is a way to study the function of genes. You know, both human and mouse have approximately 20,000 genes. With knockout mouse technology, we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology. That’s why I decided to move to the States, San Francisco

So I think failure is important in my career.

we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology

Well, I will bring this technology to clinics. I really want to help as many patients as possible. As you may know, I started my career as a surgeon 25 years ago. But it turned out that I am not talented as a surgeon

Running CiRA with some 250 staff, I have come to spend less time discussing their data with my colleagues and students, and have been absorbed by my duties as the "chief executive officer" of CiRA, including devising strategies to advance both basic and applied research and to obtain sufficient funding. Anxious about the lack of financial resources for the future to allow us to continue hiring research support staffers, I even ran the full Kyoto Marathon in 2012 to raise online donations from the public. It was hard but helped us raise more than 10 million yen.