What is the biggest obstacle you have faced professionally?

Originally asked

The American Academy of Achievement, to its honourees, its oral-history interviews

The Academy of Achievement repeatedly asks honorees to identify a major professional obstacle or challenge and describe confronting it.

You answer as yourself. Nobody on FLAPSS answers as anybody else.

Recorded Shinya Yamanaka said elsewhere, not written here
my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

Academy of Achievement interviewer, Academy of Achievement interview, 2008 source ↗

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I realized that the biggest obstacle was my mind. It was the biggest obstacle, and if I could get out of the way of myself, I would grow. So every time I had that attitude, I changed it, and I’d say, “You can. Today you can, and take it one day at a time, and today, I’m going to get up and I’m not going to think about the other six days of this week. I’m going to get up right now, and I’m going to go to the gym, and I’m going to learn about my boxing, and I’m going to be in the moment.” You know, in anything, you hit a wall, and then you have to break through it, and I just had to get out of my own way.
Recorded Academy of Achievement, Academy of Achievement interview, Los Angeles, California, 1 April 2006 source ↗
Jocelyn Bell Burnell Radio astronomer; discoverer of pulsars
Tony was cautious. He suspected I’d wired the radio telescope up wrong. So we checked on another radio telescope on the site. The thing was pulsing nicely on mine but as we stood by the pen recorder of this other telescope, nothing happened. It was a horrible moment. And suddenly there it was, five minutes later because we had miscalculated when the telescope would see it. If we’d miscalculated by 25 minutes, we’d have all gone home and the story would be different.
Recorded Louise Walsh, University of Cambridge 'Journeys of Discovery' interview series, 1 January 2020 source ↗
Mario Molina Atmospheric chemist; Nobel laureate in Chemistry, 1995
In terms of this issue of these industrial gases affecting the environment, at the beginning the road was not easy, because we were suggesting that society had to change, that industries had to do something different than they were doing at that time. And of course, initially we did not meet with a good reception to these ideas from industry. And even from the scientific community — even though our ideas were well received in the small group of specialists in what we were doing — it was not necessarily well received by the scientific community at large. So we really had to continue doing as good a science as we could, and at the same time trying to well communicate our conviction that it was something important, something that had to change in the way society was functioning.
Recorded Academy of Achievement interview, Sun Valley, Idaho, 29 June 1996 source ↗
John M. Martinis Physicist; Nobel laureate in Physics, 2025
I would say there are many challenges, and that's kind of what's hard about it. And my particular thesis, since leaving Google and doing my own company, is that building a quantum computer is a little bit harder than the scientists think about because of the system engineering. Building a powerful computer is hard. So what we're particularly working on is the manufacturing of qubits and doing that much better than what people are doing right now. I really enjoyed being in academia, and even at Google working on that. But I really enjoy right now trying to think very practically about what we have to do to get this to work. And what kind of people we have to collaborate with in order to put all the pieces together and build a quantum computer in a cost effective, economic way that makes business sense.
Recorded Adam Smith, Telephone interview recorded shortly after the prize announcement, October 2025, Nobel Prize Outreach, 1 October 2025 source ↗

More from Shinya Yamanaka

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Question What problem are you still trying to solve? Craft & work
we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology
Recorded Academy of Achievement interviewer, Academy of Achievement interview, 2008 source ↗
Question What is one of the best or most worthwhile investments you have ever made — of money, time, or energy? Money & investment
However, it was very natural that a failed surgeon with little experience in molecular biology had a hard time finding a position. A turning point came when I got a fax from Thomas Innerarity at the Gladstone Institute of Cardiovascular Diseases in San Francisco. After a short telephone conversation, Tom was brave enough to give me a postdoctoral position in his lab! Working at Gladstone was one of the best decisions I ever made in my life.
Recorded Laureate-written autobiography for Les Prix Nobel, Nobel Prize Outreach, 1 December 2012 source ↗
Question What are you most proud of? Identity & self
I strongly feel that this is, that I am able to receive this award because of John Gurdon and also many other researchers in the field. This field has a long history, starting with John Gurdon. So I feel very lucky. I may have played some important role in this long history, but it was not myself who initiated this field. So that’s my feeling right now.
Recorded Adam Smith, Telephone interview recorded shortly after the prize announcement, October 2012, Nobel Prize Outreach, 1 October 2012 source ↗
Question What advice would you give your twenty-year-old self, and what should they ignore? Time & hindsight
Well, I will bring this technology to clinics. I really want to help as many patients as possible. As you may know, I started my career as a surgeon 25 years ago. But it turned out that I am not talented as a surgeon
Recorded Adam Smith, Telephone interview recorded shortly after the prize announcement, October 2012, Nobel Prize Outreach, 1 October 2012 source ↗

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John M. Martinis, Mario Molina, Jocelyn Bell Burnell, Katalin Karikó, Richard Feynman, John Clauser

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