This cockroach-like existence is cumulatively intolerable even though on any given night it is perfectly manageable. “Cockroach” is of course an allusion to Kafka’s Metamorphosis, in which the protagonist wakes up one morning to discover that he has been transformed into an insect. The point of the story is as much the responses and incomprehension of his family as it is the account of his own sensations, and it is hard to resist the thought that even the best-meaning and most generously thoughtful friend or relative cannot hope to understand the sense of isolation and imprisonment that this disease imposes upon its victims.

We would constantly have to move because we couldn't quite afford the places that we were living. And sometimes we got evicted. And it was just very, very difficult as a child to try to understand that.

At Pixar when we were making Toy Story, there came a time when we were forced to admit that the story wasn't great. It just wasn't great. We stopped production for five months.... We paid them all to twiddle their thumbs while the team perfected the story into what became Toy Story. And if they hadn't had the courage to stop, there would have never been a Toy Story the way it is, and there probably would have never been a Pixar.

Adam, if you know about 10 years ago, I was here in October because I was kicked out, from Penn, was forced to retire. Then my husband supported me and said that, you know, when finally visited in Germany and found that maybe BioNTech is the right place, then he said "Just try it and I will make sure that you don't regret." Looking back in my life he supported that I would go, and for nine years I commuted to BioNTech in Germany. I did all these experiments actually, with my own hands, I was 58 years old, I was still culturing plasmids and feeding cells, so it is very unlikely.

I had a number of very good teachers in high school, in fact. Some mathematics teachers that perhaps allowed me the freedom to go beyond the normal routine of the class and to explore some more advanced areas. The same thing happened in college. I was able to communicate with a few of my teachers and professors, and go beyond the normal expectations. And then, as I mentioned before, Professor Pimentel, my mentor for graduate studies, was really influential in terms of the influence that he had for me.

At first the research did not seem to be particularly interesting – I carried out a systematic search for processes that might destroy the CFCs in the lower atmosphere, but nothing appeared to affect them. We knew, however, that they would eventually drift to sufficiently high altitudes to be destroyed by solar radiation. The question was not only what destroys them, but more importantly, what the consequences are.

I certainly want to continue trying to understand how the global environment functions. The earth as a system is a very complicated one. And to understand it, we need very many disciplines, very many different scientists working together. I want to continue working with my specialty, which is chemistry, with the atmosphere. There is still much to learn about chemical reactions that occur out there in the air, in the atmosphere. So one of my projects now is to really learn more about this pollution that occurs in cities and that is spreading more through the globe. To learn it in enough detail so we can better tackle it, we can better come up with new ways of using energy, for example, that are not so damaging to the environment.

As I was starting my academic career, it was almost considered to be a negative signal to your career to get involved in politics ... But to me that was a sign you were doing something useful.

For me, it was just a thrill. I just remember thinking at that time, this is the sort of thing I would like to do, if I could. I did not come from a family of scientists. My father was a lawyer, my older brother was a lawyer.

I did. As a kid, I liked music. I still like it a lot of course. I used to play the violin. I did contemplate, well, maybe that’s an option. I could become a musician. Somehow my parents got some advice that unless I was willing to spend eight or 10 hours a day just playing the violin that I should just give it up. To me, that was very bad advice because you could of course, get very involved in music without being a musician. Fortunately, even though I gave up eventually playing the violin myself, I never gave up my fondness for music. But if I had a chance again, I would not give it up. I would just do it as a hobby. I think that was just because I did not get the correct advice.