This cockroach-like existence is cumulatively intolerable even though on any given night it is perfectly manageable. “Cockroach” is of course an allusion to Kafka’s Metamorphosis, in which the protagonist wakes up one morning to discover that he has been transformed into an insect. The point of the story is as much the responses and incomprehension of his family as it is the account of his own sensations, and it is hard to resist the thought that even the best-meaning and most generously thoughtful friend or relative cannot hope to understand the sense of isolation and imprisonment that this disease imposes upon its victims.

In terms of this issue of these industrial gases affecting the environment, at the beginning the road was not easy, because we were suggesting that society had to change, that industries had to do something different than they were doing at that time. And of course, initially we did not meet with a good reception to these ideas from industry. And even from the scientific community — even though our ideas were well received in the small group of specialists in what we were doing — it was not necessarily well received by the scientific community at large. So we really had to continue doing as good a science as we could, and at the same time trying to well communicate our conviction that it was something important, something that had to change in the way society was functioning.

At Cornell, I’d work on preparing my courses, and I’d go over to the library a lot and read through the Arabian Nights and ogle the girls that would go by.  But when it came time to do some research, I couldn’t get to work.  I was a little tired; I was not interested; I couldn’t do research!  This went on for what I felt was a few years, but when I go back and calculate the timing, it couldn’t have been that long.  Perhaps nowadays I wouldn’t think it was such a long time, but then, it seemed to go on for a very long time.  I simply couldn’t get started on any problem: I remember writing one or two sentences about some problem in gamma rays and then I couldn’t go any further.  I was convinced that from the war and everything (the death of my wife) I had simply burned myself out.

The second filter is to gravitate towards working on hard things. I’d love to tell you I was an immediate success after leaving Stanford… I wasn’t. Even a decade later, I felt like I wasn’t on the right path, and it took me a while to find my footing. Until I applied to Google. I had my final interview there in 2004, it was April Fool’s Day and the day Gmail launched. So when my interviewers asked me about it, I wasn’t sure if it was a joke or a real product. That’s because at the time, one gigabyte of free storage for everyone felt super ambitious, and almost impossible. A couple years into the job, I got my chance to work on a seemingly impossible problem, too. It was around this time that the internet was moving into a new phase. The web was evolving from simple web pages to rich applications. There was a group of us that felt we could reimagine the browser to be much better and faster, and we had an early prototype that we thought was pretty good. Internally there was a consensus that building a browser would be incredibly difficult, requiring hundreds of engineers; we had a group of about ten. The consensus was right. It was going to be really hard. In some ways we were naive, and it's good to be a bit irrational when you approach new things. And in 2008, we launched what we thought was a great browser. We had eight million users in the first twenty-four hours, and the reviews were really positive. And then user growth stagnated. After a year, we had around two percent share. I remember Steve Ballmer, the CEO of Microsoft, made fun of Chrome in an interview and called it a rounding error. It could have been demoralizing. But with that California optimism, I told the team that the fact he went out of his way to dismiss us meant we were doing something right. We kept going, setting highly aggressive stretch goals to keep the team pushing. We rapidly iterated, shipping the browser every six weeks while others shipped one maybe every six months to a year. Success began to follow. Working on hard things has taught me a lot: It typically attracts other great and optimistic people. And even if you miss meeting the high goals you set, you’ll still achieve something great. So when you have the choice to work on something hard — say yes. Do what excites you

I was very, very thorough, making sure I really understood how that telescope worked, and that it was working properly. I was quite convinced that I wasn't clever enough to be in Cambridge and would be thrown out at some stage. My policy was to work as hard as I could so that I'd know I'd done my best. We now label this as impostor syndrome, but we didn't recognise, and certainly didn't name it, back then.

My contemporaries were more upset about the Nobel than I was not to be recognised. One of them labelled it the 'No-Bell' prize! But it was fine by me. There's no Nobel Prize in astronomy and I was really proud that it was my stars that had convinced the prize committee that there was good physics in astrophysics.

They have a lot of extreme physics going on inside them and scientists use them to test theories of relativity on a cosmic scale. Einstein’s theories are checking out pretty well so far.

Yes, in 2018, I was awarded the Breakthrough Prize for the discovery. I was a bit dumbstruck, never expecting that kind of thing to happen. I was keen that the money should be used well and the best way to do that seemed to be to encourage a more diverse research student population from under-represented groups.

I was really proud that it was my stars that had convinced the prize committee that there was good physics in astrophysics.

The next generation of telescopes will see millions of events per night with computers that sift through huge amounts of data. If we had had access to a computer, we would never have programmed it to look for something so unexpected. How do you pick up the things you don't know exist, the things you can't tell it to look for? My project was to study quasars, and then we accidentally stumble over these things called pulsars. They were totally unexpected, totally unknown – and it's been huge fun.