For me, no word comes without prior thought. No sentence is generated without effort. No formulation is made automatically. I am faced continually with a mystery that other people have no conception of, the mystery of the generation of speech. There is no command situation, it goes back and back and back. Where the self lies at the heart of the utterance, the speaker generating the word, is always clouded. This is true for everyone, but for most people this is not something to think about. The generation of words is automatic. For me, that automatic link is broken. Word generation involves strain, guesswork, difficulty, imprecision.

There were lots of times, especially in the early days, that were very, very difficult. I think the most difficult experience I had was in 1990 when Oracle had its only loss quarter in history. We’d been in business for 20 years, and after 20 years we lost money one quarter. We had a very difficult time. We had virtually doubled our sales every year for ten years. Nine out of ten years, ten out of eleven years. It was really quite an amazing run. We were the fastest growing company in history

But, of course, we had one problem that the modern mountaineer doesn’t have. That is, this psychological barrier. We really didn’t know whether it was humanly possible to reach the top of Mt. Everest. And even using oxygen as we were, if we did get to the top, we weren’t at all sure whether we wouldn’t drop dead or something of that nature. All the physiologists had warned us that the altitude at the summit of Everest was a very marginal altitude and might be extremely dangerous. So, one had this feeling in your mind all the time that maybe you were pushing things a bit beyond what humans were meant to do and you couldn’t ignore that feeling. But, because of strong motivation, you keep plugging on and you seem to be going okay and nothing seems to be going wrong, so you persist. And we persisted, of course, and ultimately, set foot on the summit.

Adam, if you know about 10 years ago, I was here in October because I was kicked out, from Penn, was forced to retire. Then my husband supported me and said that, you know, when finally visited in Germany and found that maybe BioNTech is the right place, then he said "Just try it and I will make sure that you don't regret." Looking back in my life he supported that I would go, and for nine years I commuted to BioNTech in Germany. I did all these experiments actually, with my own hands, I was 58 years old, I was still culturing plasmids and feeding cells, so it is very unlikely.

I don’t know. I know the ones that are the greatest triumphs, like the Dumbarton Oaks Museum in Washington D.C. that I worked on with the owners. It was a real collaboration and there was no budget, no money involved. It was just, “If we like that better, we’ll do it that way.” So I had total freedom and it was a simple project to build a little museum, and the owner and I worked together and it was pure delight from beginning to end and it came out very well.

Only Mies influenced me. Le Corbusier I met. He was a nasty man, but obviously a genius. You don’t have to like the people just because they’re geniuses. Mies and I got along better and we became pretty close. I worked with him on his greatest building here, the Seagram building, which was kind of fun, but again, you can’t be a hero-worshipper and be an uncommon architect; you’ve got to be your own man. So I split with Mies and did a different kind of work.