Although my years at Irvine were very productive, I missed not doing experiments myself because of the many responsibilities associated with a faculty position: teaching courses, supervising graduate students, meetings, etc. After spending seven years at Irvine as Assistant and then Associate Professor, I decided to move to a non-academic position. I joined the Molecular Physics and Chemistry Section at the Jet Propulsion Laboratory in 1982. I had a smaller group – only a few postdoctoral fellows – but I also had the luxury of conducting experiments with my own hands, which I enjoyed very much.

I’ve been emphasising here the small and the private, because essentially that’s what my work is about. One person writing in a quiet room, trying to connect with another person, reading in another quiet – or maybe not so quiet – room. Stories can entertain, sometimes teach or argue a point. But for me the essential thing is that they communicate feelings. That they appeal to what we share as human beings across our borders and divides. There are large glamorous industries around stories; the book industry, the movie industry, the television industry, the theatre industry. But in the end, stories are about one person saying to another: This is the way it feels to me. Can you understand what I’m saying? Does it also feel this way to you?

What is rewarding about the priesthood is, one, that you have an incredible privilege of being privy to some of the most extraordinary things about people. I mean, as their parish priest, you visit people who are sick, say, on their death bed and they tell you things that they probably have not shared with any other person. You are privileged to bring the Holy Sacrament to people at a time when they are probably at their lowest. But you also have the privilege of meeting up with people at their moment of great joy, when they are getting married, or when they have a child baptized.

And now, what are those of us who are elected public officials supposed to do? We call ourselves "public servants" but I'll tell you this: We as public servants must set an example for the rest of the nation. It is hypocritical for the public official to admonish and exhort the people to uphold the common good if we are derelict in upholding the common good. More is required -- More is required of public officials than slogans and handshakes and press releases. More is required. We must hold ourselves strictly accountable. We must provide the people with a vision of the future.

A book also pushed me to become a medical doctor. I was deeply inspired by Torao Tokuda, a physician who founded a hospital group in the 1970s that tried to revolutionize the Japanese medical care system.

Well actually I was at home. I was doing some housework. So I was very surprised.

my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

I strongly feel that this is, that I am able to receive this award because of John Gurdon and also many other researchers in the field. This field has a long history, starting with John Gurdon. So I feel very lucky. I may have played some important role in this long history, but it was not myself who initiated this field. So that’s my feeling right now.

I got very interested in so-called “knockout mouse” technology. Knockout mouse is a way to study the function of genes. You know, both human and mouse have approximately 20,000 genes. With knockout mouse technology, we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology. That’s why I decided to move to the States, San Francisco

Working at the hospital, I found that my surgical skills were not as good as I expected. One time it took me two hours to do a surgical operation which could have been completed in 30 minutes by other surgeons. My supervisors were very tough on new residents like me, and I lost confidence in my ability.