What advice would you give your twenty-year-old self, and what should they ignore?
Recorded Winston Churchill said elsewhere, not written here
Come on now all you young men, all over the world. You are needed more than ever now to fill the gap of a generation shorn by the War. You have not an hour to lose. You must take your places in life's fighting line. Twenty to twenty-five! These are the years! Don't be content with things as they are. 'The earth is yours and the fulness thereof'. Enter upon your inheritance, accept your responsibilities. Raise the glorious flags again, advance them upon the new enemies, who constantly gather upon the front of the human army, and have only to be assaulted to be overthrown. Don't take No for an answer. Never submit to failure.

Chapter of his autobiography, written at Chartwell in 1930, Winston S. Churchill, My Early Life (Thornton Butterworth, 1930), Project Gutenberg Canada, October 1930 source ↗

Others on this question

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Mario Molina Atmospheric chemist; Nobel laureate in Chemistry, 1995
The advice that I would give is try to find something that you like. Try to devote your energies to being very good at it. Try to achieve excellence. Don’t necessarily have as a goal success or getting prizes or whatever, but just doing very good work. And work hard. Keep working at it. Be patient. Realize that you don’t always see the benefits of what you’re doing, short-term. But in the end, the activities that I do, for example, scientific research, can be extremely rewarding. It’s really a very fascinating career.
Recorded Academy of Achievement interview, Sun Valley, Idaho, 29 June 1996 source ↗
Whitney Wolfe Herd Founder and chief executive of Bumble
I think fear and fear of the unknown and perceived failure is what holds people back. For me, I am more scared of complacency than having something not work out. I'd rather take a leap of faith and fall than stand on the edge forever.
Recorded CNBC Make It interview, conducted 2019, 11 February 2021 source ↗
Denton Cooley Cardiothoracic surgeon; founder of the Texas Heart Institute
You have to be intelligent, and be able to cope with stress. It is a stressful life, both mentally and physically. Those are the qualities to succeed as a surgeon.
Recorded Academy of Achievement recorded interview, American Academy of Achievement, 11 April 1991 source ↗
Frederick Sanger Biochemist; twice a Nobel laureate in Chemistry, 1958 and 1980
Get on with it. But make sure you do want to do it. I think that’s the important thing, to be something that you would enjoy. If you only just go into science to get rich or to win gold medals, then I wouldn’t bother, but if you really want to enjoy yourself in the lab, then do it.
Recorded Academy of Achievement interview, 28 October 2000 source ↗

More from Winston Churchill

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Question What did you want to be when you were growing up? Identity & self
At the end he asked me if I would like to go into the Army. I thought it would be splendid to command an Army, so I said 'Yes' at once: and immediately I was taken at my word. ... I was told later that he had only come to the conclusion that I was not clever enough to go to the Bar. However that may be, the toy soldiers turned the current of my life.
Recorded Chapter of his autobiography, written at Chartwell in 1930, Winston S. Churchill, My Early Life (Thornton Butterworth, 1930), Project Gutenberg Canada, October 1930 source ↗
Question Who do you turn to when you need advice? Relationships
My mother made the same brilliant impression upon my childhood's eye. She shone for me like the Evening Star. I loved her dearly—but at a distance. My nurse was my confidante. Mrs. Everest it was who looked after me and tended all my wants. It was to her I poured out my many troubles, both now and in my schooldays.
Recorded Chapter of his autobiography, written at Chartwell in 1930, Winston S. Churchill, My Early Life (Thornton Butterworth, 1930), Project Gutenberg Canada, October 1930 source ↗
Question How close have you come to death? Death & what remains
But in a flash there came across me a great project. The chine which the bridge spanned was full of young fir trees. Their slender tops reached to the level of the footway. 'Would it not' I asked myself 'be possible to leap on to one of them and slip down the pole-like stem, breaking off each tier of branches as one descended, until the fall was broken?' I looked at it. I computed it. I meditated. Meanwhile I climbed over the balustrade. My young pursuers stood wonder-struck at either end of the bridge. To plunge or not to plunge, that was the question! In a second I had plunged, throwing out my arms to embrace the summit of the fir tree. The argument was correct; the data were absolutely wrong. It was three days before I regained consciousness and more than three months before I crawled from my bed. The measured fall was 29 feet on to hard ground. But no doubt the branches helped.
Recorded Chapter of his autobiography, written at Chartwell in 1930, Winston S. Churchill, My Early Life (Thornton Butterworth, 1930), Project Gutenberg Canada, October 1930 source ↗
Question In the last five years, what have you become better at saying no to? Daily life
I hope not too much on them. Well, really, we have to concentrate on the grim emergencies, and when we have solved them, we shall be in a position to deal with the future of the world in a manner to give the best results, and the most lasting results, for the common peoples of all the lands. But one has only a certain amount of life and strength, and only so many hours in the day, and other emergencies press upon us too much to be drawn into those very, very complicated, tangled, and not in all cases attractive jungles.
Recorded An unnamed correspondent at the White House press conference, Joint press conference with President Franklin D. Roosevelt, the White House, The American Presidency Project, 23 December 1941 source ↗
Question What happens when we die? Death & what remains
I cannot pretend to feel impartial about the colours. I rejoice with the brilliant ones, and am genuinely sorry for the poor browns. When I get to heaven I mean to spend a considerable portion of my first million years in painting, and so get to the bottom of the subject. But then I shall require a still gayer palette than I get here below. I expect orange and vermilion will be the darkest, dullest colours upon it, and beyond them there will be a whole range of wonderful new colours which will delight the celestial eye.
Recorded Essay first published in the Strand Magazine in 1921–22 and collected in Amid These Storms, 1932, Winston S. Churchill, Painting as a Pastime, Project Gutenberg Canada, 1932 source ↗
Question When were you happiest? Time & hindsight
But the years 1895 to 1900 which are the staple of this story exceed in vividness, variety and exertion anything I have known—except of course the opening months of the Great War. When I look back upon them I cannot but return my sincere thanks to the high gods for the gift of existence. All the days were good and each day better than the other. Ups and downs, risks and journeys, but always the sense of motion, and the illusion of hope.
Recorded Chapter of his autobiography, written at Chartwell in 1930, Winston S. Churchill, My Early Life (Thornton Butterworth, 1930), Project Gutenberg Canada, October 1930 source ↗

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