Totally. I’d say parents, brothers, sisters, and don’t go far beyond that for the moment. If you’ve had a long-term relationship with an agent, that’s a whole different thing, because that agent is there to care.

But I need to show my work during the process. In the editing room, very often I invite friends and I do some test screenings with friends or people I know: editors, journalists sometimes. I ask them, Is it boring? Is it too long? What do you think?

I prayed a lot about it. I sought a lot of advice from my dad.

People refer to the ‘LMB culture’ as the thing, one of the things, that makes it special. It’s an attention to people who are willing to tackle very big problems. I mean problems that are so big that you couldn’t just solve it in a grant. The kind of problem that you could devote your life to. I was very fortunate in having mentors of Fred Sanger and César Milstein who exercised a kind of very benign mentorship but encouraged us to think big.

I cannot pretend to feel impartial about the colours. I rejoice with the brilliant ones, and am genuinely sorry for the poor browns. When I get to heaven I mean to spend a considerable portion of my first million years in painting, and so get to the bottom of the subject. But then I shall require a still gayer palette than I get here below. I expect orange and vermilion will be the darkest, dullest colours upon it, and beyond them there will be a whole range of wonderful new colours which will delight the celestial eye.

First of all, you can correct mistakes much more easily. One sweep of the palette-knife 'lifts' the blood and tears of a morning from the canvas and enables a fresh start to be made; indeed the canvas is all the better for past impressions.

But in a flash there came across me a great project. The chine which the bridge spanned was full of young fir trees. Their slender tops reached to the level of the footway. 'Would it not' I asked myself 'be possible to leap on to one of them and slip down the pole-like stem, breaking off each tier of branches as one descended, until the fall was broken?' I looked at it. I computed it. I meditated. Meanwhile I climbed over the balustrade. My young pursuers stood wonder-struck at either end of the bridge. To plunge or not to plunge, that was the question! In a second I had plunged, throwing out my arms to embrace the summit of the fir tree. The argument was correct; the data were absolutely wrong. It was three days before I regained consciousness and more than three months before I crawled from my bed. The measured fall was 29 feet on to hard ground. But no doubt the branches helped.

Painting is complete as a distraction. I know of nothing which, without exhausting the body, more entirely absorbs the mind. Whatever the worries of the hour or the threats of the future, once the picture has begun to flow along, there is no room for them in the mental screen. They pass out into shadow and darkness. All one's mental light, such as it is, becomes concentrated on the task. Time stands respectfully aside, and it is only after many hesitations that luncheon knocks gruffly at the door.

Prisoner of War! That is the least unfortunate kind of prisoner to be, but it is nevertheless a melancholy state. You are in the power of your enemy. You owe your life to his humanity, and your daily bread to his compassion. You must obey his orders, go where he tells you, stay where you are bid, await his pleasure, possess your soul in patience. Meanwhile the war is going on, great events are in progress, fine opportunities for action and adventure are slipping away. Also the days are very long. Hours crawl like paralytic centipedes. Nothing amuses you. Reading is difficult; writing impossible. Life is one long boredom from dawn till slumber. Moreover, the whole atmosphere of prison, even the most easy and best regulated prison, is odious. Companions in this kind of misfortune quarrel about trifles and get the least possible pleasure from each other's society. If you have never been under restraint before and never known what it was to be a captive, you feel a sense of constant humiliation in being confined to a narrow space, fenced in by railings and wire, watched by armed men, and webbed about with a tangle of regulations and restrictions. I certainly hated every minute of my captivity more than I have ever hated any other period in my whole life. ... Therefore in after years, when I was Home Secretary and had all the prisons of England in my charge, I did my utmost consistent with public policy to introduce some sort of variety and indulgence into the life of their inmates, to give to educated minds books to feed on

The cultivation of a hobby and new forms of interest is therefore a policy of first importance to a public man. But this is not a business that can be undertaken in a day or swiftly improvised by a mere command of the will. The growth of alternative mental interests is a long process. The seeds must be carefully chosen; they must fall on good ground; they must be sedulously tended, if the vivifying fruits are to be at hand when needed. To be really happy and really safe, one ought to have at least two or three hobbies, and they must all be real.