In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.

I continued the work on dorsal, discovered the recessive phenotype and interpreted the phenotype postulating a gradient determining the dorsoventral axis. At that time, gradients were not widely accepted as mechanisms, in particular biochemists were highly sceptical, however the Tübingen influence made such models attractive to me.

And in all of that time I won a nickname, ``The Great Communicator.'' But I never thought it was my style or the words I used that made a difference: it was the content. I wasn't a great communicator, but I communicated great things, and they didn't spring full bloom from my brow, they came from the heart of a great nation -- from our experience, our wisdom, and our belief in the principles that have guided us for two centuries.

What I want to do this morning is share with you a couple of stories and talk about a different Africa. Already this morning there were some allusions to the Africa that you hear about all the time: the Africa of HIV/AIDS, the Africa of malaria, the Africa of poverty, the Africa of conflict, and the Africa of disasters. While it is true that those things are going on, there's an Africa that you don't hear about very much. And sometimes I'm puzzled, and I ask myself why. This is the Africa that is changing, that Chris alluded to. This is the Africa of opportunity. This is the Africa where people want to take charge of their own futures and their own destinies.

I think three things. One is the great advances in auto safety. I mean, there are tens of thousands of people being saved every year because cars are safer, and millions of people over a decade, injuries prevented. I think that’s a good example of the need to make technology more humane. We may benefit from a lot of technologies, but they exact a cost. Emphysema, cancer, soil contamination, contaminated water, death and injury on the highway. We’ve got to put more effort on making them more humane.

We used to converse at dinner time around the table. Parents and children. We talked about all kinds of issues. From local, neighborhood issues to world issues. It was back and forth, very lively, and very critical. During our early years my mother would relate historical sagas to us for five or ten minutes every lunch hour, when we would come home from school, and it would be continued the next day. I think that built into us a sense that freedom involves responsibility. It isn’t just waving flags and saying, “Look how free we are,” while people’s rights are being trampled sometimes overtly, sometimes beyond their control.

But if it did well, I’d remember what my parents told me, which was the hardest thing is not attaining success, it’s being able to endure it.