Oh ya, I doubted more than expected. I had doubts all the time. The way was extremely, extremely difficult. … At one point I had to describe what I am doing to a person who is a great intellectual but not a scientist, and I told him what we felt is that we are climbing mountains in order to reach the climax – and these mountains are like the Everest, the biggest most difficult to climb – only to find out that there is another mountain waiting behind it to be climbed afterwards. So every climbing was an achievement but there was a bigger problem behind it or above it. I had lots of minutes that I didn't expect, but I thought science in general and this science particularly is worth the effort – even if we would never get the ultimate result.

If you get stuck, get away from your desk. Take a walk, take a bath, go to sleep, make a pie, draw, listen to ­music, meditate, exercise; whatever you do, don’t just stick there scowling at the problem. But don’t make telephone calls or go to a party; if you do, other people’s words will pour in where your lost words should be. Open a gap for them, create a space. Be patient.

And when things get tough, this is what you should do. Make good art. I’m serious. Husband runs off with a politician? Make good art. Leg crushed and then eaten by mutated boa constrictor? Make good art. IRS on your trail? Make good art. Cat exploded? Make good art. Somebody on the Internet thinks what you do is stupid or evil or it’s all been done before? Make good art. Probably things will work out somehow, and eventually time will take the sting away, but that doesn’t matter. Do what only you do best. Make good art.

Sometimes when I'm in the first round or second round, and I'm not playing well, I say, okay, just accept it. Don't get frustrated. Just accept and focus.