What does everyone in your world seem to agree on that you think is wrong?

To the extent that we ignore this, forget about it, become complacent, or believe that it is so infinite that it can take care of itself, we are in trouble.

I continued the work on dorsal, discovered the recessive phenotype and interpreted the phenotype postulating a gradient determining the dorsoventral axis. At that time, gradients were not widely accepted as mechanisms, in particular biochemists were highly sceptical, however the Tübingen influence made such models attractive to me.

Instant information about everything and everyone often allows an individual opinion to compete with consensus and paranoia with evidence. It is a time when one blunt honest statement can finish a life-long political career, and one opinionated journalist can bully a government or a royal family. Science is not immune from such pressures. For example, how many Nobel prize-winning experiments – you think – would have been stopped, if ethics or health-and-safety regulations at that time were as zealous as they are today? I can think of more than a few.

In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.

Well, I'm proud of my gender. I think, you know, and I've said this to my Berkeley colleagues this morning, but my feeling is that I think among women and girls that, you know, sometimes there's a sense that no matter what they do that their work will not be recognised the way it would be if they were a man. And I just … I hope that this prize and this recognition changes that at least a little bit, and that it's encouraging to other women who are in science, or even in other fields, to realise that, you know, their work can be honoured and that their work can have a real impact.