What is something everyone in your world agrees about that you think is wrong?

When you are famous it is hard to work on small problems. This is what did Shannon in. After information theory, what do you do for an encore? The great scientists often make this error. They fail to continue to plant the little acorns from which the mighty oak trees grow. They try to get the big thing right off. And that isn't the way things go. So that is another reason why you find that when you get early recognition it seems to sterilize you. In fact I will give you my favorite quotation of many years. The Institute for Advanced Study in Princeton, in my opinion, has ruined more good scientists than any institution has created, judged by what they did before they came and judged by what they did after.

To the extent that we ignore this, forget about it, become complacent, or believe that it is so infinite that it can take care of itself, we are in trouble.

I continued the work on dorsal, discovered the recessive phenotype and interpreted the phenotype postulating a gradient determining the dorsoventral axis. At that time, gradients were not widely accepted as mechanisms, in particular biochemists were highly sceptical, however the Tübingen influence made such models attractive to me.

And yet, despite the high moral and ethical quality of social commiseration, political dedication and a deep commitment to equity, there was something rather disturbing about standard leftwing politics of that time: in particular, its scepticism of process-oriented political thinking, including democratic procedures that permit pluralism. The major institutions of democracy got no more credit than what could be portioned out to what was seen as "bourgeois democracy," on the deficiencies of which the critics were most vocal. The power of money in many democratic practices was rightly identified, but the alternatives – including the terrible abuses of non-oppositional politics – did not receive serious critical scrutiny.

Under the stress of the event, we felt, the soldiers' true nature would reveal itself, and we would be able to tell who would be a good leader and who would not. But the trouble was that, in fact, we could not tell. Every month or so we had a "statistics day," during which we would get feedback from the officer-training school, indicating the accuracy of our ratings of candidates' potential. The story was always the same: our ability to predict performance at the school was negligible. But the next day, there would be another batch of candidates to be taken to the obstacle field, where we would face them with the wall and see their true natures revealed. I was so impressed by the complete lack of connection between the statistical information and the compelling experience of insight that I coined a term for it: "the illusion of validity."

However, I should say that the education system in Iran is not the way people might imagine here. As a graduate student at Harvard, I had to explain quite a few times that I was allowed to attend a university as a woman in Iran. While it is true that boys and girls go to separate schools up to high school, this does not prevent them from participating say in the Olympiads or the summer camps.

Yes, and, I'll turn your comment around and say it's fairly close to the biological ratio of men and women. It's all the other fields that are aberrant. … This is the normal field, right? Because it is a much more even distribution between men and women, absolutely.

Yes, we're showing that. But we're also showing a very important role for face-to-face or even written communication. So, the prediction was that nobody would self-monitor because that's a second level social dilemma, if you go to Game Theory. But, what we've found is that people will, but it can be … people can escalate into, 'I'll punish you, you punish him, mamamamamma,' and it gets worse and worse. So, with communication, where there's an agreement on what is going to be the … what we are going to do. The 'we' then being well-defined, then people can follow rules, be cooperative and, occasionally, sanction one another to help that continue.

Instant information about everything and everyone often allows an individual opinion to compete with consensus and paranoia with evidence. It is a time when one blunt honest statement can finish a life-long political career, and one opinionated journalist can bully a government or a royal family. Science is not immune from such pressures. For example, how many Nobel prize-winning experiments – you think – would have been stopped, if ethics or health-and-safety regulations at that time were as zealous as they are today? I can think of more than a few.

There was very much a real feel that we probably pretty much discovered every major fossil field in Africa. And in fact, some scientists even wrote that down at the turn of the millennia. It wasn’t a great time to be proposing to explore and push new, because we hadn’t succeeded, theoretically, being given the chance. All the big discoveries were in old sites. ... I was still an extraordinary believer in that there was more out there to be discovered. I just wasn’t demonstrating.

In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.

As I was starting my academic career, it was almost considered to be a negative signal to your career to get involved in politics ... But to me that was a sign you were doing something useful.

I think it's … the profession is starting to realise that in part it's the general climate, and the way we treat each other is not conducive for having more women in the profession. It's not just about promotion but it's about the general environment and how people talk to each other and address each other in seminars and things like that, that we need to work on a culture that is more respectful and that will be more acceptable for many women who think that they don't want to play the games of shouting at each other.

The next generation of telescopes will see millions of events per night with computers that sift through huge amounts of data. If we had had access to a computer, we would never have programmed it to look for something so unexpected. How do you pick up the things you don't know exist, the things you can't tell it to look for? My project was to study quasars, and then we accidentally stumble over these things called pulsars. They were totally unexpected, totally unknown – and it's been huge fun.

Now according to me, and this is my cosmology scheme, which I'm having trouble persuading the cosmologists about, is that when the universe is rid of pretty well all its matter, it in a certain sense forgets how big it is. Now that's a crazy idea, but you see if you don't have any mass around you don't have any way of scaling the size of the universe, and so it in effect becomes the big bang of the next aeon as I'm calling it – A E O N. So according to my scheme, the universe as we currently understand it, which is from big bang, and then there's this inflationary phase which I don't believe in, which is supposed to take place very, very early on, and then the universe has this more sedate expansion, and then it has another exponential expansion, and that's it. According to me, that's not it. It morphs into the next big bang.

Well, I'm proud of my gender. I think, you know, and I've said this to my Berkeley colleagues this morning, but my feeling is that I think among women and girls that, you know, sometimes there's a sense that no matter what they do that their work will not be recognised the way it would be if they were a man. And I just … I hope that this prize and this recognition changes that at least a little bit, and that it's encouraging to other women who are in science, or even in other fields, to realise that, you know, their work can be honoured and that their work can have a real impact.

I’d read some of the things that Don Glaser wrote, for example, and they’re imaginative physics, they’re not quite such good biology. There was a consensus that said you had to be able to reach out from physics and get to some of these things you’d like to, but then you have to know enough about the biology that the whole thing makes sense. And you really have to present things in such a way that a community develops. I didn’t realize that at the time, but certainly one of the important things of what I did had to do with enabling people who came from physics, or who came from biology, become a community, working on not just one little problem or piece, but somehow collectively working together toward trying to get an understanding.

The culture in the East is a little bit strange to me. People are too nice, they’re very obedient and do not challenge authority. I think you should be a little more chaotic, rude and daring.

I’ve been mortally opposed to the so-called life-and-death committees that were instituted. When there were many more patients that needed to be dialyzed, and not enough artificial kidneys available, you had the institution of the life-and-death committees. ... Depending on the answer to these questions, he could be dialyzed. Otherwise, he could go to hell. I’ve been mortally opposed to that. When I set up a dialysis center here with a grant from some government agency, I was forced to put in a life-and-death committee, but it never met.

Today, in my opinion, people are more interested in the number of papers and the way of judging people has become much more statistical. Pupils are already doing this right from the beginning. Also, very few people go into basic science, there’s a big thing about making money e.g. biotech. Some people view education as a tool for making money or at least for making a good life, rather than understanding and digging down into something, which was my motivation.