I would have to take longer than a minute to give my whole synopsis of my life, but I want to let you know that all of us should be free and equal and have equal opportunity and that is what I’m trying to instill and encourage and inspire young people to reach their highest potential.

Oh God, there are so many beautiful things in the world which I will have to leave when I die but I'm ready, I'm ready, I'm ready. ... And I don't know whether I'll do another book or not. I might. It doesn't matter. I'm a happy old man. But I will cry my way all the way to the grave.

As I’ve gotten older, my goals have become more solidified. My main concentration is on the welfare of the people I’ve worked with in the Himalayas and on human welfare in general. I’m also extremely interested in the environment and trying to encourage people to be more concerned about what we’re doing to our world. Now I’m just one of thousands and thousands of people who have these same views these days. I think this is one of the great steps forward we’ve seen in modern decades — the considerable growing interest that people have in the environment and in keeping it reasonably clean and wholesome. I certainly hope it remains that way.

There is an even longer shot that I do propose to attempt even though its likely efficacy lies at the outer limits of probability. I am going to try to have my entire DNA “sequenced,” along with the genome of my tumor. ... So perhaps I will be able to contribute a little bit to enlarging the knowledge that will help future generations.

But the satisfactions of compensation are notoriously fleeting. There is no saving grace in being confined to an iron suit, cold and unforgiving. The pleasures of mental agility are much overstated, inevitably—as it now appears to me—by those not exclusively dependent upon them. Much the same can be said of well-meaning encouragements to find nonphysical compensations for physical inadequacy. That way lies futility. Loss is loss, and nothing is gained by calling it by a nicer name. My nights are intriguing; but I could do without them.

But if I was sitting in an armchair with bits and pieces of rubber sticking out of me and my son came over and said, you know, would you like a banana? Wink once for yes, wink twice for no, I dont think the interest of the conversation would get me past the sense that this is horrible. It's horrible for me but above all, horrible for them. There are things worse than death.

During the day I can at least request a scratch, an adjustment, a drink, or simply a gratuitous re-placement of my limbs—since enforced stillness for hours on end is not only physically uncomfortable but psychologically close to intolerable. It is not as though you lose the desire to stretch, to bend, to stand or lie or run or even exercise. But when the urge comes over you there is nothing—nothing—that you can do except seek some tiny substitute or else find a way to suppress the thought and the accompanying muscle memory.

I was forced to think very hard about what it meant to be me, what it means to be a person who is only a brain. Pascal's 'thinking reed' really does capture it, because I'm just a bunch of dead muscles thinking.

I don't believe in an afterlife. I don't believe in a single or multiple godhead. I respect people who do, but I don't believe it myself. But there's a big but which enters in here. I am much more conscious than I ever was, for obvious reasons, of what it will mean to people left behind once I'm dead. It won't mean anything for me. But it will mean a lot to them. ... So in one curious way I've come to believe in the afterlife as a place where I still have moral responsibilities, just as I do in this life except that I can only exercise them before I get there. Once I get there, it'll be too late.

This cockroach-like existence is cumulatively intolerable even though on any given night it is perfectly manageable. “Cockroach” is of course an allusion to Kafka’s Metamorphosis, in which the protagonist wakes up one morning to discover that he has been transformed into an insect. The point of the story is as much the responses and incomprehension of his family as it is the account of his own sensations, and it is hard to resist the thought that even the best-meaning and most generously thoughtful friend or relative cannot hope to understand the sense of isolation and imprisonment that this disease imposes upon its victims.