And democracy requires compromise, even when you are 100 percent right. This is hard to explain sometimes. You can be completely right, and you still are going to have to engage folks who disagree with you. If you think that the only way forward is to be as uncompromising as possible, you will feel good about yourself, you will enjoy a certain moral purity, but you're not going to get what you want.

Our trouble is that we do not demand enough of the people who represent us. We are responsible for their activities… we must spur them to more imagination and enterprise in making a push into the unknown; we must make clear that we intend to have responsible and courageous leadership.

I will start by stating the obvious. No one here questions whether development is desirable. No one questions the inherent need to save lives and help others by giving. However, I believe that we need to rethink the ways in which we help others. We need to give from the perspective of empowering the recipient, instead of making them dependent on us.

In Japan, however, I found myself suffering from Post America Depression or PAD. The environment for researchers in Japan was quite different in many ways from that in the U.S. At the medical school, very few scientists showed interest in the basic biology of mouse ES cells, and there was little thought-provoking discussion with my colleagues. Some of my colleagues advised me to work on something more related to medicine. Furthermore, I could not get enough funding and had to change the cages of the numerous mice by myself every week. What was worse, the Nat1 work was being rejected by many journals. I felt lonely and depressed, and I was about to give up my career as a scientist and return to the path of physician.

So any student who wants to get into psychology, right now the students are like lemmings. They say, “Well, it’s popular to study brain science, I’ll do that.” Or, “It’s popular to do neural networks; I see 30,000 people doing it, it must be good.” And my advice is if a lot of people are doing it, don’t waste your time.