I would advise them to aim high. To set their sights at a pretty tough target and don’t be too worried if you’re not successful at first. Just keep persisting and keep improving your standards, getting better and better and ultimately, you’ve got a pretty fair chance at achieving your desired goal. ... But, I do think that virtually everybody that’s born has the ability to be very competent at doing something. I think that, in itself, is worthy of aiming towards, just to be competent at doing anything you particularly wish to do.

The first thing to recommend is that they don’t work in some place that they don’t like, that they don’t do things that they don’t like. That they look for what they really want to do and what kind of thing they want to be involved in, or if they want to go it alone by themselves, to find that.

My last piece of advice is the one I could have used the most. It took me a long time to learn. And it is this: You are not a slacker if you cut yourself some slack. When I was your age, I didn't believe in vacations. I didn't believe in weekends. I pushed everyone around me to work very long hours. In the early days of Microsoft, my office overlooked the parking lot—and I would keep track of who was leaving early and staying late. But as I got older—and especially once I became a father—I realized there is more to life than work. Don't wait as long as I did to learn this lesson.

I think a lot of people, when they’re really young, and in their 20s, they are on their own quest for personal efficacy. And I understand that. ... But the sooner that people can discover that it’s really about building teams, and not about personal efficacy, I think the better — the more quickly — we can move forward. I believe that.

I think so. I really do. With your own effort, you can improve yourself, but people find they can’t improve beyond a certain point. I like to play golf, but I know that no matter how much I practice, I will never get above a certain level. I think that’s also true of surgery. Some people are born with the gifts and the mind for surgery, and they may go on to great heights. Others may try and try, only to reach a certain plateau.

I don’t lead by force, I lead by example. And if I can, set a good example. If I can set an example to my staff and my group, by being punctual, I come to work every morning, walk onto the hospital floor within two or three minutes of the same time every day, and they can depend upon it.

The man who inspired me most, I think, was Dr. Alfred Blalock, who was professor of surgery at Johns Hopkins. He was a rather simple man with a burning curiosity. It was through his curiosity that he made many real contributions to medical science. I didn’t think he was an especially brilliant man, I just admired him for his curiosity, and for his perseverance.