What is the biggest obstacle you have faced professionally?

At Cornell, I’d work on preparing my courses, and I’d go over to the library a lot and read through the Arabian Nights and ogle the girls that would go by.  But when it came time to do some research, I couldn’t get to work.  I was a little tired; I was not interested; I couldn’t do research!  This went on for what I felt was a few years, but when I go back and calculate the timing, it couldn’t have been that long.  Perhaps nowadays I wouldn’t think it was such a long time, but then, it seemed to go on for a very long time.  I simply couldn’t get started on any problem: I remember writing one or two sentences about some problem in gamma rays and then I couldn’t go any further.  I was convinced that from the war and everything (the death of my wife) I had simply burned myself out.

More than anything else, I had to combat the barriers, and we tore down those barriers. I just had to set a sail against the wind, those strong winds, to end segregation and racial discrimination, but somehow, in some way, I didn’t let those barriers keep me down.

No. Unfortunately, it hasn’t worked out quite that way. At that time, everybody was euphoric that we will have a new world order, you know, a world order that does not rely on nuclear weapons, nuclear deterrence. Unfortunately, it didn’t work that way. ... We still have thousands of warheads in existence. We still have more than 20 — 30 countries relying on nuclear deterrence for their own survival.

This cockroach-like existence is cumulatively intolerable even though on any given night it is perfectly manageable. “Cockroach” is of course an allusion to Kafka’s Metamorphosis, in which the protagonist wakes up one morning to discover that he has been transformed into an insect. The point of the story is as much the responses and incomprehension of his family as it is the account of his own sensations, and it is hard to resist the thought that even the best-meaning and most generously thoughtful friend or relative cannot hope to understand the sense of isolation and imprisonment that this disease imposes upon its victims.

Myself, I love the imagery of struggle. I sometimes wish I were suffering in a good cause, or risking my life for the good of others, instead of just being a gravely endangered patient. Allow me to inform you, though, that when you sit in a room with a set of other finalists, and kindly people bring a huge transparent bag of poison and plug it into your arm, and you either read or don’t read a book while the venom sack gradually empties itself into your system, the image of the ardent soldier or revolutionary is the very last one that will occur to you. You feel swamped with passivity and impotence: dissolving in powerlessness like a sugar lump in water.

Adam, if you know about 10 years ago, I was here in October because I was kicked out, from Penn, was forced to retire. Then my husband supported me and said that, you know, when finally visited in Germany and found that maybe BioNTech is the right place, then he said "Just try it and I will make sure that you don't regret." Looking back in my life he supported that I would go, and for nine years I commuted to BioNTech in Germany. I did all these experiments actually, with my own hands, I was 58 years old, I was still culturing plasmids and feeding cells, so it is very unlikely.

I would say there are many challenges, and that's kind of what's hard about it. And my particular thesis, since leaving Google and doing my own company, is that building a quantum computer is a little bit harder than the scientists think about because of the system engineering. Building a powerful computer is hard. So what we're particularly working on is the manufacturing of qubits and doing that much better than what people are doing right now. I really enjoyed being in academia, and even at Google working on that. But I really enjoy right now trying to think very practically about what we have to do to get this to work. And what kind of people we have to collaborate with in order to put all the pieces together and build a quantum computer in a cost effective, economic way that makes business sense.