What is the biggest obstacle you have faced professionally?

At Cornell, I’d work on preparing my courses, and I’d go over to the library a lot and read through the Arabian Nights and ogle the girls that would go by.  But when it came time to do some research, I couldn’t get to work.  I was a little tired; I was not interested; I couldn’t do research!  This went on for what I felt was a few years, but when I go back and calculate the timing, it couldn’t have been that long.  Perhaps nowadays I wouldn’t think it was such a long time, but then, it seemed to go on for a very long time.  I simply couldn’t get started on any problem: I remember writing one or two sentences about some problem in gamma rays and then I couldn’t go any further.  I was convinced that from the war and everything (the death of my wife) I had simply burned myself out.

In terms of this issue of these industrial gases affecting the environment, at the beginning the road was not easy, because we were suggesting that society had to change, that industries had to do something different than they were doing at that time. And of course, initially we did not meet with a good reception to these ideas from industry. And even from the scientific community — even though our ideas were well received in the small group of specialists in what we were doing — it was not necessarily well received by the scientific community at large. So we really had to continue doing as good a science as we could, and at the same time trying to well communicate our conviction that it was something important, something that had to change in the way society was functioning.

my second failure in my career. But that second failure got me interested in knockout mice, mouse technology. So I think failure is important in my career

Tony was cautious. He suspected I’d wired the radio telescope up wrong. So we checked on another radio telescope on the site. The thing was pulsing nicely on mine but as we stood by the pen recorder of this other telescope, nothing happened. It was a horrible moment. And suddenly there it was, five minutes later because we had miscalculated when the telescope would see it. If we’d miscalculated by 25 minutes, we’d have all gone home and the story would be different.

The hard part was getting around this, this was a religion among physicists, and in fact even in the Bohr-Einstein debates, and with Schrödinger also, the universal religion was quantum mechanics makes correct predictions, period, no, off the table. What Bell's theorem and in particular our version of it, the Clauser-Horne-Shimony-Holt experimental prediction, showed that either that had to be wrong, nor Einstein's whole legacy had to be wrong. I think at the time people who were critical of doing the experiment didn't realise really what was at stake, that it was that cut and dried between two religious icons, if you will, the field of physics. Since I kind of was the inventor of the CHSH inequality and the CH inequality and all that, I knew exactly what it was all about. But it took a long time for that to filter in.

Adam, if you know about 10 years ago, I was here in October because I was kicked out, from Penn, was forced to retire. Then my husband supported me and said that, you know, when finally visited in Germany and found that maybe BioNTech is the right place, then he said "Just try it and I will make sure that you don't regret." Looking back in my life he supported that I would go, and for nine years I commuted to BioNTech in Germany. I did all these experiments actually, with my own hands, I was 58 years old, I was still culturing plasmids and feeding cells, so it is very unlikely.

I would say there are many challenges, and that's kind of what's hard about it. And my particular thesis, since leaving Google and doing my own company, is that building a quantum computer is a little bit harder than the scientists think about because of the system engineering. Building a powerful computer is hard. So what we're particularly working on is the manufacturing of qubits and doing that much better than what people are doing right now. I really enjoyed being in academia, and even at Google working on that. But I really enjoy right now trying to think very practically about what we have to do to get this to work. And what kind of people we have to collaborate with in order to put all the pieces together and build a quantum computer in a cost effective, economic way that makes business sense.