Tony was cautious. He suspected I’d wired the radio telescope up wrong. So we checked on another radio telescope on the site. The thing was pulsing nicely on mine but as we stood by the pen recorder of this other telescope, nothing happened. It was a horrible moment. And suddenly there it was, five minutes later because we had miscalculated when the telescope would see it. If we’d miscalculated by 25 minutes, we’d have all gone home and the story would be different.

Adam, if you know about 10 years ago, I was here in October because I was kicked out, from Penn, was forced to retire. Then my husband supported me and said that, you know, when finally visited in Germany and found that maybe BioNTech is the right place, then he said "Just try it and I will make sure that you don't regret." Looking back in my life he supported that I would go, and for nine years I commuted to BioNTech in Germany. I did all these experiments actually, with my own hands, I was 58 years old, I was still culturing plasmids and feeding cells, so it is very unlikely.

At Pixar when we were making Toy Story, there came a time when we were forced to admit that the story wasn't great. It just wasn't great. We stopped production for five months.... We paid them all to twiddle their thumbs while the team perfected the story into what became Toy Story. And if they hadn't had the courage to stop, there would have never been a Toy Story the way it is, and there probably would have never been a Pixar.

We would constantly have to move because we couldn't quite afford the places that we were living. And sometimes we got evicted. And it was just very, very difficult as a child to try to understand that.

The first principle is that you must not fool yourself—and you are the easiest person to fool. So you have to be very careful about that. After you've not fooled yourself, it's easy not to fool other scientists. You just have to be honest in a conventional way after that.

Nothing happens because there’s not enough real activity and challenge: You’re not in contact with the experimental guys.  You don’t have to think how to answer questions from the students.  Nothing!

one of my diseases, one of my things in life, is that anything that is secret I try to undo. And so the locks to those filing cabinets represented a challenge to me. How the hell to open them? So I worked and worked on them. There are all kinds of stories about how you can feel the numbers and listen to things and so on. That's true; I understand it very well - for old- 19 fashioned safes. But these had a new design so that nothing would be pushing against the wheels while you were trying them, and none of the old methods would work. I read books by locksmiths, which always say in the beginning how they opened the locks when the safe is under water and the woman in it is drowning or some-thing, and the great locksmith opened the safe. And then in the back they tell you how they do it, and they don't tell you anything sensible. It doesn't sound like they could really open safes that way — like guess the combination on the basis of the psychology of the person who owns it! So I always figured they were keeping the method a secret, and like a kind of disease, I kept working on these things until I found out a few things. First, I found out how big a range you need to open the combination, how close you have to be. And then I invented a system by which you could try all the necessary combinations - 8,000, as it turned out, because the woman DROWNING عزه Books are always telling how the great locksmith opens the safe under water when the woman in it is drowning. 20 you could be within two of every number. And then I worked out a scheme by which I could try numbers without altering a number that I had already set, by correctly moving the wheels, so that I could try all the combinations in eight hours. And then finally I discovered (this took me about two years of researching) that it's easy to take the last two numbers of the combination off the safe if the safe is open. If the drawer was pulled out, you could turn the number and see the bolt go up and play around and find out what number it comes back at, and stuff like that. With a little trickery, you can get the combination off. So I used to practice it like a cardsharp practices cards, you know - all the time. Quicker and quicker and more and more unobtrusively I would come in and talk to some guy. I'd sort of lean against his filing cabinet, and you wouldn't even notice I'm doing any-thing. I'm not doing anything— just playing with the dial, that's all, just playing with the dial. But all the time I was taking the two numbers off! And then I would go back to my office and write the two numbers down, the last two numbers of the three. Now, if you have the last two numbers, it takes just a minute to try for the first number; there's only 20 possibilities, and it's open. OK? It takes about three minutes to open a safe if you know the last two numbers. So I got an excellent reputation for safe-cracking.

So I got this new attitude.  Now that I am burned out and I’ll never accomplish anything, I’ve got this nice position at the university teaching classes which I rather enjoy, and just like I read the Arabian Nights for pleasure, I’m going to play with physics, whenever I want to, without worrying about any importance whatsoever.

Then there was Von Neumann, the great mathemati-cian. We used to go for walks on Sunday. We'd walk in the canyons, and we'd often walk with Bethe, and Von Neumann, and Bacher. It was a great pleasure. And Von Neumann gave me an interesting idea; that you don't have to be responsible for the world that you're in.

It is necessary, I believe, to accept this idea, not only for science, but also for other things; it is of great value to acknowledge ignorance.  It is a fact that when we make decisions in our life we don't necessarily know that we are making them correctly; we only think that we are doing the best we can – and that is what we should do.