we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology

I think a lot of that first wave of entrepreneurship was missing the product of localization, and they weren't really asking the question, "What are the big, impactful products or problems that we got to solve locally, and forget about the U.S. or forget about Europe?"

we know the fish, we know the worm, we know the fly, but we don’t know the links between and we don’t know, when we go back to the branches in evolution, we really don’t know what happened there when they branched and how they divert and what is the major drive for evolution.

We have all these interesting challenges now. No one knows whether automation and robotics, nanotechnology, will kill more jobs than it creates. If it does, that presents a serious problem. What are we going to do? Have a few of us work to support everybody else, or shorten the workweek for everybody? If so, how do we get from here to there? No one knows yet how we’re going to stop cyber terrorism from wrecking honest discourse in democracy and maybe putting our very lives at risk.

Well, then of course, came the disaster in 1975, when my wife and my youngest daughter were flying into the Nepal hills where I was building a hospital and their plane crashed and they were killed. And this certainly, for me, was an absolute disaster, really because the two people that meant most to me in life had been killed in one fell swoop. It did take me quite a number of years to get over it. I found the only way to deal with it was to carry on very energetically, doing the things that we had all been doing together, which was largely building schools and things for the mountain people. Although, people used to say to me, “Time is the great healer,” certainly for the first two years I simply didn’t accept this. But, time was a great healer and after the years passed, the memories still remain. But, I think quite a lot of the pain tends to fade a little bit, and life did become a little bit easier.

I still regard adventure pretty much as a hobby to tell you the honest truth, and I think this approach to it keeps one refreshed almost. I think if you just regard adventure as a business, working becomes very boring as many other businesses can become. But even though adventure changed my life considerably, both in what I was doing and even economically, I’ve always regarded myself in a sense as a competent amateur.

The press and the public have created an image of Ed Hillary, hero and explorer which simply doesn’t exist. They’ve painted a picture of me as a heroic type, full of enormous courage, tremendous strength, undying enthusiasm and all the rest of it. But it’s all really just a story, that’s been written up in the newspapers. I’m a person, as I’ve said, of modest abilities, with a good deal of determination, and I do quite a lot of planning ahead. With careful planning and good motivation, I think you can often achieve things that other much more talented people would probably do much more easily.

As I’ve gotten older, my goals have become more solidified. My main concentration is on the welfare of the people I’ve worked with in the Himalayas and on human welfare in general. I’m also extremely interested in the environment and trying to encourage people to be more concerned about what we’re doing to our world. Now I’m just one of thousands and thousands of people who have these same views these days. I think this is one of the great steps forward we’ve seen in modern decades — the considerable growing interest that people have in the environment and in keeping it reasonably clean and wholesome. I certainly hope it remains that way.

I did have — definitely — one heroic figure who impressed me very much indeed, and that was the great Antarctic explorer, Shackleton. Shackleton I always admired because he was a tough man and a very good leader. And whenever he was in difficult circumstances, which he frequently was, he seemed to have the great ability to inspire his men and lead his party safely out of those conditions. So certainly Shackleton, I would have said, more than anything, was a role model for me.

Well my memory for names is absolutely appalling, but I know I did pass through a phase of books like King Solomon’s Mines. H. Rider Haggard was the author, and he wrote these great romantic adventure stories. I used to enjoy Georgette Heyer, in which the hero was usually a rather middle-aged gentleman, a very good sword fighter, with a beautiful young lady and all the rest of it. Great sword fighting and all highly romantic, adventurous activity. I used to find these things quite entertaining. I even passed through a phase when I quite enjoyed Western stories. Nowadays, I find them a little on the naive side but, for a period, I found the Western stories quite entertaining light reading. They are very romanticized, as we all know. Later on, I became much more interested in reading biographies, particularly about people who had made their mark in the community. I still enjoy reading books of that nature.