What advice would you give your twenty-year-old self, and what should they ignore?

You never follow the crowd. You work things out for yourself. And therefore if you think differently from the crowd, you must put your own view and try to get people taking your line. But you never follow the crowd. You never do things just because other people are doing them.

Sensitivity. Be sensitive in every way possible about everything in life. Be sensitive. Insensitivity brings indifference and nothing is worse than indifference. Indifference makes that person dead before the person dies.

Having advanced well beyond what the French call "a certain age," I am often asked to convey to younger people helpful advice and counsel. So I will open these remarks with the best advice I ever received. The advice, which I have several times shared with others, was given to me by my mother-in-law on my wedding day. She had a prescription for a happy, enduring marriage: "It pays," she said, "it pays sometimes to be a little deaf."

so I sometimes think, why should I talk young women into being a scientist if they then end up being sort of disliked or not accepted by their contemporaries and so it’s a tricky business actually.

It’s very hard to give people advice, because you don’t know their personality. Personality is a big part of that. Everybody is faced with passing opportunities. Many people watch the opportunity come and watch it go. I say, if an opportunity comes and you have got the self-confidence, grab it. Ride it for a bit. If it’s not the right opportunity, do something else, but be positive about opportunities.

My advice to everyone is: “Become a journalist.” ... if you have a chance to be a newspaper reporter for three or four years — before you do whatever you want to do — do it, because you will know so much.

The first thing to recommend is that they don’t work in some place that they don’t like, that they don’t do things that they don’t like. That they look for what they really want to do and what kind of thing they want to be involved in, or if they want to go it alone by themselves, to find that.

Marry somebody you love and who thinks you being a writer’s a good idea.

Build a good name. Keep your name clean. Don’t make compromises. Don’t worry about making a bunch of money or being successful. Be concerned about doing good work and protect your work. […] Protect your work and if you build a good name, eventually that name will be its own currency.

One thing I state as soon as we’re out of the door: ‘Under no circumstances is anyone to say that I lost a battle with cancer. Or that I bore it bravely. I am not fighting, losing, winning or bearing.’ I will not personify the cancer cells inside me in any form. I reject all metaphors of attack or enmity in the midst, and will have nothing whatever to do with any notion of desert, punishment, fairness or unfairness, or any kind of moral causality.

It’s a very interesting and challenging field! It’s important to study math and science throughout high school and college, and major in some technical area. Take advantage of all of the opportunities that colleges provide, including professor office hours, tutoring, student chapters of organizations like Society of Hispanic Professional Engineers (SHPE) and Society of Physics Students (SPS), and project-based hands-on classes.

Don't screw it up. Don't take it for granted. Try new things, even if you're old. Do the right thing, because if you do the right thing, the money will follow. Decide what you stand for. Finally, don't worry about being cool—be warm.

My last piece of advice is the one I could have used the most. It took me a long time to learn. And it is this: You are not a slacker if you cut yourself some slack. When I was your age, I didn't believe in vacations. I didn't believe in weekends. I pushed everyone around me to work very long hours. In the early days of Microsoft, my office overlooked the parking lot—and I would keep track of who was leaving early and staying late. But as I got older—and especially once I became a father—I realized there is more to life than work. Don't wait as long as I did to learn this lesson.