Never give up your passion for learning. And zoom out of your field before you zoom in. Some of my very best business insights have come from reading around subjects. They have come from approaching questions at a strange angle, from thinking about them from a different point of view. A lot of the knowledge that has really given me an edge in business has come from history, psychology, even chemistry. Connecting seemingly unconnected dots is what has served me well.

Scientists are people who are curious and want to pursue knowledge and pursue truth, and this still remains the most timeless and priceless value of a scientific career. My advice to an early-career scientist is to remain true to your passion and curiosity and that sense of mission to discover knowledge and uncover innovation. It's also very important to be using the tools of the moment, of the century. There are a lot of new tools to uplevel our own scientific research and scientific quest.

So take the time to find the thing that excites you more than anything else in the world. Not the thing your parents want you to do. Or the thing that all your friends are doing. Or that society expects of you.

By the way, the guys with very high grades are not necessarily the people that are the most successful in later life. They may be the ones that can regurgitate gracefully, and they get very high grades. But if the guys that have to work for it and do not have such good grades can do something extra, and prove that they can perform, they may have a chance.

I wish I had learned more from failure than just mortification. I don’t think you learn much from success, and I don’t think you learn much from failure, unfortunately. It’s one of the sad things. You certainly learn that it’s more fun to have a hit than a flop.

The movies I made that didn't work.

People think that when you write something it’s cathartic, and I had written a lot of personal articles at Esquire, and people always say, “Oh God, it must have been so great when you finally wrote about having small breasts.” No. You get through that, and then you write it. It is not the writing that is the catharsis.

Yesterday – I had a delicious tomato sandwich, on toasted sourdough bread, with mayonnaise.

Yes. I had a couple of great, great teachers. The teacher who changed my life was my journalism teacher, whose name was Charles Simms. I always tell this story. I love it. I had already decided that I was going to be a journalist. I didn’t know why exactly, except that I had seen a lot of Superman comics. Lois Lane and all of those major literary characters like that, but Mr. Simms got up the first day of class, and he went to the blackboard, and he wrote “Who, what, where, why, when, and how,” which are the six things that have to be in the lead of any newspaper story. Then he did what most journalism teachers do, which is that he dictated a set of facts to us, and then we were all meant to write the lead that was supposed to have “who, what, where, why, when, and how” in it. He dictated a set of facts that went something like, “The principal of Beverly Hills High School announced today that the faculty of the high school will travel to Sacramento, Thursday, for a colloquium in new teaching methods. Speaking there will be Margaret Mead, the anthropologist, and two other people.” So we all sat down at our typewriters, and we all kind of inverted that and wrote, “Margaret Mead and X and Y will address the faculty in Sacramento, Thursday, at a colloquium on new teaching methods, the principal announced today.” Something like that. We were very proud of ourselves, and we gave it to Mr. Simms, and he just riffled through them and tore them into tiny bits and threw them in the trash, and he said, “The lead to this story is: There will be no school Thursday!” and it was this great epiphany moment for me. It was this, “Oh my God, it is about the point! It is about figuring out what the point is.” And I just fell in love with journalism at that moment. I just fell in love with the idea that underneath, if you sifted through enough facts, you could get to the point, and you had to get to the point. You could not miss the point. That would be bad. So he really kind of gave that little shift of mind a major push.