What is one of the best investments you have made — of money, time, or energy?

So I find that teaching and the students keep life going, and I would never accept any position in which somebody has invented a happy solution for me where I don’t have to teach.  Never.

My science family came from all over the world, and members were of varied backgrounds, cultures, and abilities. The diversity in this "small world" I worked in daily provided the most stimulating environment, with many challenges and much optimism. Over the years, my research group has had close to 150 graduate students, postdoctoral fellows, and visiting associates. Many of them are now in leading academic, industrial and governmental positions. Working with such minds in a village of science has been the most rewarding experience – Caltech was the right place for me.

Amos and I shared the wonder of together owning a goose that could lay golden eggs – a joint mind that was better than our separate minds. … Some of the greatest joys of our collaboration-and probably much of its success – came from our ability to elaborate each other's nascent thoughts: if I expressed a half-formed idea, I knew that Amos would be there to understand it, probably more clearly than I did, and that if it had merit he would see it. Like most people, I am somewhat cautious about exposing tentative thoughts to others – I must first make sure that they are not idiotic. In the best years of the collaboration, this caution was completely absent.

Sherry offered me a list of research options: the one project that intrigued me the most consisted of finding out the environmental fate of certain very inert industrial chemicals – the chlorofluorocarbons (CFCs) – which had been accumulating in the atmosphere and which at that time were thought to have no significant effects on the environment. This project offered me the opportunity to learn a new field – atmospheric chemistry – about which I knew very little; trying to solve a challenging problem appeared to be an excellent way to plunge into a new research area.

No, because I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology. And we felt, no matter, anything we do to chip away at the problem would be useful. So it was more that that attracted me. And I think the fact that it was large and kind of difficult to come to grips with, yes, it was attractive. Really what was attractive was that it was a fundamental problem.

However, it was very natural that a failed surgeon with little experience in molecular biology had a hard time finding a position. A turning point came when I got a fax from Thomas Innerarity at the Gladstone Institute of Cardiovascular Diseases in San Francisco. After a short telephone conversation, Tom was brave enough to give me a postdoctoral position in his lab! Working at Gladstone was one of the best decisions I ever made in my life.

Yes, in 2018, I was awarded the Breakthrough Prize for the discovery. I was a bit dumbstruck, never expecting that kind of thing to happen. I was keen that the money should be used well and the best way to do that seemed to be to encourage a more diverse research student population from under-represented groups.

And also I have to say this is also part of the reason why I approached Jennifer Doudna, also, you know, we were very much in line in the way to do very precise research. It was not … it was fast but precise, and deep. For this we recognised one another – we are the same type of scientist who, you know, want to see the details of the data.

And like most nurses, I found myself running into certain frustrations. I started to look for ways to make a better argument, to advocate more convincingly for the people under my care. That led me to read up on civil law and produce a few research papers, and then I did a master’s degree in health science and also an MBA. All of that allowed me to see other sides of the problem. It also showed me how issues affecting nurses could be elevated by approaching ministers and other people in power with sound, evidence-based arguments.

Well, it is of course a step-by-step process that started back in the 80s. I was struggling to retrieve a little bit of DNA from things that were just a few … starting with just dried tissues that, you know, that were just a few months old, going back in time and struggling with the technological issues with that over a decade. And then it became possible to retrieve DNA from things like the mammoths or cave bears that lived at a similar time as the Neanderthals. And then I was very lucky to get a job in Germany, where of course Neanderthals is a big presence in our, in the imagination of people, so it was then very, an obvious next step, in a way, to try to do that.