One of the saints in my life is this woman named Imogene Hill, who was a fourth-grade teacher who taught this advanced class. She got hip to my whole situation in about a month and kindled a passion in me for learning things. I learned more that year than I think I learned in any year in school.

At this school I was allowed to learn things which interested me: French, History, lots of Poetry by heart, and above all Riding and Swimming. The impression of those years makes a pleasant picture in my mind, in strong contrast to my earlier schoolday memories.

I got very interested in so-called “knockout mouse” technology. Knockout mouse is a way to study the function of genes. You know, both human and mouse have approximately 20,000 genes. With knockout mouse technology, we can select one gene out of those 20,000 genes, and completely destroy that one particular gene so that we can understand the function of that particular gene. I got very interested in that technology. It was 1992 or 1993 when I graduated from my Ph.D. school. So I decided to study — I decided to learn about knockout mouse technology. But at that time in Japan, only a few scientists were working on knockout mouse technology. That’s why I decided to move to the States, San Francisco

I think a very big curiosity. I’m very curious and I like to understand things and not only science but also other things where I just try to find out why things work or how things work. Science and nature caught my attention as a small child already. I was growing up in a city but we had a garden and I loved the garden and then often on vacation I was at a farm and I loved these animals and plants and so on, so I was attracted very early on and then we had a very good teaching actually at my … I don’t know whether my teachers really had much of a role because I was determined very early, but then I also did music and I did languages and Literature and so on. I have broad interests actually other than science, but this is really true, this curiosity.

Although my years at Irvine were very productive, I missed not doing experiments myself because of the many responsibilities associated with a faculty position: teaching courses, supervising graduate students, meetings, etc. After spending seven years at Irvine as Assistant and then Associate Professor, I decided to move to a non-academic position. I joined the Molecular Physics and Chemistry Section at the Jet Propulsion Laboratory in 1982. I had a smaller group – only a few postdoctoral fellows – but I also had the luxury of conducting experiments with my own hands, which I enjoyed very much.

At first the research did not seem to be particularly interesting – I carried out a systematic search for processes that might destroy the CFCs in the lower atmosphere, but nothing appeared to affect them. We knew, however, that they would eventually drift to sufficiently high altitudes to be destroyed by solar radiation. The question was not only what destroys them, but more importantly, what the consequences are.

It’s easy to try to exaggerate the problems just to get more attention. So for me, it was very clear that the best way to deal with that was to do the best science that I was capable of doing.

So achievement, to me, is something that just comes with this attitude of doing your work the best you can in a passionate way. It’s not something that you have to expect. It’s something that’s a consequence of what you do, but it’s certainly important.

I then converted a bathroom, seldom used by the family, into a laboratory and spent hours playing with chemistry sets. With the help of an aunt, Esther Molina, who was a chemist, I continued with more challenging experiments along the lines of those carried out by freshman chemistry students in college.

Certainly not. As a young child, I remember just dreaming about the Nobel Prize, but that was just a dream. It’s not something I would have ever thought was possible for me.